ArticleGenome medicine2010
Collaboratively charting the gene-to-phenotype network of human congenital heart defects.
Article in Genome medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Decoding the complex genetic causes of heart diseases using systems biology.Biophysical reviews · 2015Article
- Cytogenomic Evaluation of Subjects with Syndromic and Nonsyndromic Conotruncal Heart Defects.BioMed research international · 2015Article
- Novel loci for non-syndromic coarctation of the aorta in sporadic and familial cases.PloS one · 2015Article
- Genetic basis of congenital cardiovascular malformations.European journal of medical genetics · 2014Review
- Transcriptional atlas of cardiogenesis maps congenital heart disease interactome.Physiological genomics · 2014Article
- Rare variants in NR2F2 cause congenital heart defects in humans.American journal of human genetics · 2014Article
- Identification of novel candidate gene loci and increased sex chromosome aneuploidy among infants with conotruncal heart defects.American journal of medical genetics. Part A · 2014Article
- Computational tools for prioritizing candidate genes: boosting disease gene discovery.Nature reviews. Genetics · 2012Review
- Human gene copy number spectra analysis in congenital heart malformations.Physiological genomics · 2012Article
- Haploinsufficiency of TAB2 causes congenital heart defects in humans.American journal of human genetics · 2010Article
- Hierarchical approaches for systems modeling in cardiac development.Wiley interdisciplinary reviews. Systems biology and medicineReview
- 2010 translational bioinformatics year in review.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHow to efficiently integrate the daily practice of molecular biologists, geneticists, and clinicians with the emerging computational strategies from systems biology is still much of an open question. DESCRIPTION: We built on the recent advances in Wiki-based technologies to develop a collaborative knowledge base and gene prioritization portal aimed at mapping genes and genomic regions, and untangling their relations with corresponding human phenotypes, congenital heart defects (CHDs). This portal is not only an evolving community repository of current knowledge on the genetic basis of CHDs, but also a collaborative environment for the study of candidate genes potentially implicated in CHDs - in particular by integrating recent strategies for the statistical prioritization of candidate genes. It thus serves and connects the broad community that is facing CHDs, ranging from the pediatric cardiologist and clinical geneticist to the basic investigator of cardiogenesis.
conclusionsThis study describes the first specialized portal to collaboratively annotate and analyze gene-phenotype networks. Of broad interest to the biological community, we argue that such portals will play a significant role in systems biology studies of numerous complex biological processes.CHDWiki is accessible at http://www.esat.kuleuven.be/~bioiuser/chdwiki.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.