ArticleSource code for biology and medicine2010
MADAM - An open source meta-analysis toolbox for R and Bioconductor.
Article in Source code for biology and medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
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- A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections.BMC systems biology · 2011Pooled it
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- Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses.European journal of human genetics : EJHG · 2022Article
- Genetic association between CD96 locus and immunogenicity to anti-TNF therapy in Crohn's disease.The pharmacogenomics journal · 2019Article
- Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.PLoS genetics · 2015Article
- Impact of Statins on Gene Expression in Human Lung Tissues.PloS one · 2015Article
- Neuromolecular responses to social challenge: common mechanisms across mouse, stickleback fish, and honey bee.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Proteomic mapping of proteins released during necrosis and apoptosis from cultured neonatal cardiac myocytes.American journal of physiology. Cell physiology · 2014Article
- Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications.PloS one · 2012Article
- MicroRNA-centric measurement improves functional enrichment analysis of co-expressed and differentially expressed microRNA clusters.BMC genomics · 2012Article
- Empirical comparison of cross-platform normalization methods for gene expression data.BMC bioinformatics · 2011Article
- Revisiting Information Technology tools serving authorship and editorship: a case-guided tutorial to statistical analysis and plagiarism detection.Hippokratia · 2010Article
- Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeta-analysis is a major theme in biomedical research. In the present paper we introduce a package for R and Bioconductor that provides useful tools for performing this type of work. One idea behind the development of MADAM was that many meta-analysis methods, which are available in R, are not able to use the capacities of parallel computing yet. In this first version, we implemented one meta-analysis method in such a parallel manner. Additionally, we provide tools for combining the results from a set of methods in an ensemble approach. Functionality for visualization of results is also provided.
resultsThe presented package enables the carrying out of meta-analysis either by providing functions directly or by wrapping them to existing implementations. Overall, five different meta-analysis methods are now usable through MADAM, along with another three methods for combining the corresponding results. Visualizing the results is eased by three included functions. For developing and testing meta-analysis methods, a mock up data generator is integrated.
conclusionsThe use of MADAM enables a user to focus on one package, in turn enabling them to work with the same data types across a set of methods. By making use of the snow package, MADAM can be made compatible with an existing parallel computing infrastructure. MADAM is open source and freely available within CRAN http://cran.r-project.org.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.