Evidence map›Paper›PMID 20192779›Full record

ReviewAnnual review of biophysics2010

Expanding roles for diverse physical phenomena during the origin of life.

Itay Budin, Jack W Szostak

Abstract readReview
In one paragraph

Review in Annual review of biophysics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Review
  2. Article
  3. Theory for sequence selection via phase separation and oligomerization.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Can the origin of biosynthetic routes be explained by a Frankenstein's monster-like spontaneous assembly of prebiotic reactants?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  5. Thermodynamic consistency of autocatalytic cycles.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Unveiling the Effect of Myo-inositol on Primitive Cell Models Derived from Fatty Acid.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Article
  9. Chemically Driven Division of Protocells by Membrane Budding.Journal of the American Chemical Society · 2024
    Article
  10. RNA World with Inhibitors.Entropy (Basel, Switzerland) · 2024
    Article
  11. Review
  12. Article
  13. Sequence self-selection by cyclic phase separation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Role of Stress in the Origin of Life.Life (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Itay BudinDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114-2696, USA.
Jack W Szostak

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Recent synthetic approaches to understanding the origin of life have yielded insights into plausible pathways for the emergence of the first cells. Here we review current experiments with implications for the origin of life, emphasizing the ability of unexpected physical processes to facilitate the self-assembly and self-replication of the first biological systems. These laboratory efforts have uncovered novel physical mechanisms for the emergence of homochirality; the concentration and purification of prebiotic building blocks; and the ability of the first cells to assemble, grow, divide, and acquire greater complexity. In the absence of evolved biochemical capabilities, such physical processes likely played an essential role in early biology.

Indexed as

Origin of LifeCell MembranePhysical PhenomenaRNAStereoisomerismRNA

Identifiers

PMID20192779
PMCPMC4992673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.