ReviewJournal of clinical immunology2010
MicroRNA in the adaptive immune system, in sickness and in health.
Review in Journal of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- MicroRNAs orchestrating host and vector-borne protozoan interactions: bridging immune modulation and cross-species communication.Frontiers in immunology · 2025Review
- The role of microRNAs involved in the disorder of blood-brain barrier in the pathogenesis of multiple sclerosis.Frontiers in immunology · 2023Review
- MicroRNAs Dysregulation as Potential Biomarkers for Early Diagnosis of Endometriosis.Biomedicines · 2022Review
- Review
- Profiling changes in microRNAs of immature dendritic cells differentiated from human monocytes.Central-European journal of immunology · 2021Article
- Article
- Leishmania donovani infection induce differential miRNA expression in CD4+ T cells.Scientific reports · 2020Article
- miR‑146a improves hepatic lipid and glucose metabolism by targeting MED1.International journal of molecular medicine · 2020Article
- Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis.BMC genomics · 2019Article
- miR-30a inhibits breast cancer progression through the Wnt/β-catenin pathway.International journal of clinical and experimental pathology · 2019Article
- A systems immunology approach identifies the collective impact of 5 miRs in Th2 inflammation.JCI insight · 2018Article
- Cyclosporine A Induces MicroRNAs Controlling Innate Immunity during Renal Bacterial Infection.Journal of innate immunity · 2018Article
- Changes in miRNA Gene Expression during Wound Repair in Differentiated Normal Human Bronchial Epithelium.International journal of genomics · 2018Article
- miRNAs in Tuberculosis: New Avenues for Diagnosis and Host-Directed Therapy.Frontiers in microbiology · 2018Review
- Article
- Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.The Journal of clinical investigation · 2017Article
- Circulating microRNAs as Potential Biomarkers of Infectious Disease.Frontiers in immunology · 2017Review
- MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected byFrontiers in immunology · 2017Article
- Altered miRNAs expression profiles and modulation of immune response genes and proteins during neonatal sepsis.Journal of clinical immunology · 2014Article
- MicroRNA profiling of activated and tolerogenic human dendritic cells.Mediators of inflammation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMicroRNA are emerging as key regulators of the development and function of adaptive immunity. These 19-24 nucleotide regulatory RNA molecules have essential roles in multiple faucets of adaptive immunity, from regulating the development of the key cellular players to the activation and function in immune responses. DISCUSSION: MicroRNA are involved in T cell and B cell differentiation in the thymus and bone marrow, and subsequent peripheral homeostasis. The contribution of specific microRNA to the adaptive immune response becomes even more apparent during the effector phases: class switching and germinal centre formation in B cells, differentiation into functional lineages in T cells, and activation of antigen-presentation cells through pattern-recognition pathways. With the capacity of microRNA to alter the survival and death of T and B cells, control over microRNA expression is essential to prevent adaptive immune cells from unregulated proliferation. MicroRNA can act both as 'oncomirs' and tumour suppressors, and thus dysregulation of microRNA in lymphocytes can cause malignancies.
conclusionIn this review, we will describe the role of microRNA in generating a productive adaptive response, and the consequences if microRNA-mediated repression of lymphocytes is perturbed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.