ArticleBone marrow transplantation2010
Quality rather than quantity: the cord blood bank dilemma.
Article in Bone marrow transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05836974 (Performance Evaluation of the ex Utero Cord Blood Collection Technique), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Performance Evaluation of the ex Utero Cord Blood Collection Technique: Procedure, Quality and Results
Who cites it
17 citing papers in PubMed.
- Impact of length of cryopreservation and origin of cord blood units on hematologic recovery following cord blood transplantation.Bone marrow transplantation · 2015Trial
- Trial
- Qualitative and quantitative cell recovery in umbilical cord blood processed by two automated devices in routine cord blood banking: a comparative study.Blood transfusion = Trasfusione del sangue · 2013Trial
- Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts.Blood · 2011Trial
- High Integrity and Fidelity of Long-Term Cryopreserved Umbilical Cord Blood for Transplantation.Journal of clinical medicine · 2021Article
- Enumerating regulatory T cells in cryopreserved umbilical cord blood samples using FOXP3 methylation specific quantitative PCR.PloS one · 2020Article
- Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation.Cell transplantation · 2018Article
- Clinical Grade Regulatory CD4Frontiers in immunology · 2018Review
- Italian Recommendations for Placental Transfusion Strategies.Frontiers in pediatrics · 2018Review
- Detecting primitive hematopoietic stem cells in total nucleated and mononuclear cell fractions from umbilical cord blood segments and units.Journal of translational medicine · 2015Article
- The Assessment of Parameters Affecting the Quality of Cord Blood by the Appliance of the Annexin V Staining Method and Correlation with CFU Assays.Stem cells international · 2013Article
- A review of factors influencing the banking of collected umbilical cord blood units.Stem cells international · 2013Article
- The Role of HLA in Cord Blood Transplantation.Bone marrow research · 2012Article
- Trends in cord blood banking.Blood transfusion = Trasfusione del sangue · 2012Article
- Effects of obstetric factors and storage temperatures on the yield of endothelial colony forming cells from umbilical cord blood.Angiogenesis · 2011Article
- Quality assessment of umbilical cord blood units at the time of transplantation.International journal of hematology · 2011Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing inventories of cord blood units have facilitated access to umbilical cord cell transplantation for many patients lacking conventional stem cell donors. They are in principle 'off-the-shelf', 'fit-for-use', as well as safe and effective therapy products. Cellular enumeration is used as a surrogate of graft potency, and users rely on the rigorous assessment carried out in banks to avoid poor engraftment after thawing (loss of cells or poor function), when the patient's situation is critical. However, in practice, when units are selected, initially on the basis of HLA matching and cell dose assessment, their absolute quality remains uncertain. Unfortunately, quality-related issues (particularly related to viability) are not uncommon in cord blood transplantation. The reasons for potency failures are diverse, but a lack of thorough validation during critical steps of the process and of appropriate use of quality-control tools for timely detection of problematic units are significant contributors. Moreover, incongruence between different sets of standards and regulations, and lack of common quality systems between banks result in a highly heterogeneous international inventory. Therefore, this complicates the matter for the end user of the product. To ameliorate this situation, it is essential to improve quality at each of the critical manufacturing steps wherein potency can be threatened, thereby creating homogeneous inventories of units with excellent quality and quantity.
Indexed as
Identifiers
20190835What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.