ArticleNature neuroscience2010
Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep.
Article in Nature neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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Who cites it
47 citing papers in PubMed.
- Modelling vasopressin synthesis and storage dynamics during prolonged osmotic challenge and recovery based on activity dependent upregulation of mRNA transcription.PLoS computational biology · 2026Article
- Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain.eLife · 2026Article
- Excessive daytime sleepiness is independently associated with dehydration among older adults.BMC geriatrics · 2026Article
- Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons.Journal of neuroendocrinology · 2025Review
- Development and Application in Stroke of an Aldehyde nanoparticle-based Amplified Luminescent Proximity Homogeneous Assay for Rapid Quantitative Measurement of Serum Copeptin.Journal of fluorescence · 2025Article
- Elucidating the alcohol-sleep-hangover relationship in college students using a daily diary approach.Pharmacology, biochemistry, and behavior · 2025Article
- Dehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study.Nutrients · 2024Article
- Article
- Effects of a 1-hour per night week-long sleep extension in college students on cardiometabolic parameters, hydration status, and physical activity: A pilot study.Sleep health · 2024Article
- NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Development of circadian neurovascular function and its implications.Frontiers in neuroscience · 2023Review
- Arginine Vasopressin, Synaptic Plasticity, and Brain Networks.Current neuropharmacology · 2022Review
- Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain.Nature communications · 2021Article
- Purinergic P2 and glutamate NMDA receptor coupling contributes to osmotically driven excitability in hypothalamic magnocellular neurosecretory neurons.The Journal of physiology · 2021Article
- Article
- Circadian Rhythms of the Hypothalamus: From Function to Physiology.Clocks & sleep · 2021Review
- Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death.Scientific reports · 2021Article
- Article
- Circadian regulation of membrane physiology in neural oscillators throughout the brain.The European journal of neuroscience · 2020Review
- The renal molecular clock: broken by aging and restored by exercise.American journal of physiology. Renal physiology · 2019Review
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Authors and funding
2 authors.
Funding
Abstract
Osmoregulated vasopressin release is facilitated during the late sleep period (LSP) to prevent dehydration and enuresis. Previous work has shown that clock neurons in the suprachiasmatic nucleus (SCN) have low firing rates during the LSP, but it is not known how this reduced activity enhances vasopressin release. We found that synaptic excitation of rat supraoptic nucleus neurons by osmosensory afferents is facilitated during the LSP. Stimulation of the SCN at this time inhibited excitatory synaptic currents induced in supraoptic neurons by activation of osmosensory afferents. This effect was associated with an increased rate of synaptic failures and occurred without changes in frequency facilitation, quantal size or in the ratio of postsynaptic responses mediated by AMPA and NMDA receptors. We conclude that clock neurons mediate an activity-dependent presynaptic silencing of osmosensory afferent synapses onto vasopressin neurons and that osmoregulatory gain is enhanced by removal of this effect during late sleep.
Indexed as
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20190744What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.