ReviewJournal of musculoskeletal & neuronal interactions2010
The development and morphogenesis of the tendon-to-bone insertion - what development can teach us about healing -.
Review in Journal of musculoskeletal & neuronal interactions, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to-Bone Healing: A Systematic Review with Subgroup Meta-Analysis.The Iowa orthopaedic journal · 2019Pooled it
- The Biological Effect of Platelet-Rich Plasma on Subacromial Bursa and Torn Supraspinatus Tendon: A Randomized Controlled Trial.International journal of molecular sciences · 2026Trial
- Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration.Science advances · 2026Article
- Denosumab therapy is associated with a reduced risk of clinically diagnosed rotator cuff tears: a multi-institutional real-world cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Multicellular microtissues from fused ligament- and bone-cell spheroids relevant to enthesis repair.Materials today. Bio · 2026Article
- Highly bio-adapted hydrogels for tendon-bone interface regeneration: Natural healing inspiration, design strategies, and biomedical potential.Bioactive materials · 2026Review
- Anatomical design and production of a novel three-dimensional co-culture system replicating the human flexor digitorum profundus enthesis.Journal of anatomy · 2026Article
- Orchestrating the immuno-chondrogenic microenvironment via a bio-inorganic hybrid microsphere system for tendon-to-bone healing.Materials today. Bio · 2026Article
- Functionally Graded Surfaces and Materials: From Fabrication to Biomedical Applications.Chemical reviews · 2026Review
- Injectable human tendon extracellular matrix via isopropanol-assisted delipidation and mild decellularization for tendon regeneration.Frontiers in bioengineering and biotechnology · 2026Article
- Structural integrity vs. clinical utility: a critical review of bio-inductive scaffolds and autologous alternatives in rotator cuff repair.Frontiers in medicine · 2026Review
- Current Concepts in Pathogenesis and Conservative Management of Supraspinous Tendinopathies Using Shockwave Therapy-A Narrative Review of the Literature.Biomedicines · 2025Review
- Janus piezoelectric adhesives regulate macrophage TRPV1/CaBioactive materials · 2025Article
- Extrusion of Heterogeneous Filament-like Structures: A New Paradigm in Fabricating Soft Mechanical Gradient with Long Span.Small science · 2025Article
- Metabolic-associated enthesitis: a review on pathophysiology, clinical relevance, diagnostic challenges, and perspective on target treatments.Immunologic research · 2025Review
- Long-term nonsteroidal anti-inflammatory drug use is associated with rotator cuff tears in adult patients.JSES international · 2025Article
- Muscle loading and endochondral ossification are involved in the regeneration of a fibrocartilaginous enthesis during tendon to bone healing in rabbits.BMC musculoskeletal disorders · 2025Article
- Investigating the influence of mineral content changes on mechanical properties through ligament insertion.Frontiers in aging · 2025Article
- Mature murine supraspinatus tendons demonstrate regional differences in multiscale structure, function and gene expression.PloS one · 2025Article
- Exosomes derived from tendon stem/progenitor cells enhance tendon-bone interface healing after rotator cuff repair in a rat model.Bioactive materials · 2024Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The attachment of dissimilar materials is a major challenge because of the high levels of stress that develop at such interfaces. An effective solution to this problem develops at the attachment of tendon (a compliant "soft tissue") to bone (a stiff "hard tissue"). This tissue, the "enthesis", transitions from tendon to bone through gradations in structure, composition, and mechanical properties. These gradations are not regenerated during tendon-to-bone healing, leading to a high incidence of failure after surgical repair. Understanding the development of the enthesis may allow scientists to develop treatments that regenerate the natural tendon-to-bone insertion. Recent work has demonstrated that both biologic and mechanical factors drive the development and morphogenesis of the enthesis. A cascade of biologic signals similar to those seen in the growth plate promotes mineralization of cartilage on the bony end of the enthesis and the formation of fibrocartilage on the tendon end of the enthesis. Mechanical loading is also necessary for the development of the enthesis. Removal of muscle load impairs the formation of bone, fibrocartilage, and tendon at the developing enthesis. This paper reviews recent work on the development of the enthesis, with an emphasis on the roles of biologic and mechanical factors.
Indexed as
Identifiers
20190378PMC3605736What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.