ReviewJournal of musculoskeletal & neuronal interactions2010
Dynamic skeletal muscle stimulation and its potential in bone adaptation.
Review in Journal of musculoskeletal & neuronal interactions, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Biological mechanisms underlying the effects of low-magnitude mechanical stress in osteoporosis (Review).Experimental and therapeutic medicine · 2026Review
- Anatomical implant region - a critical determinant for the osteogenic potency of small extracellular vesicles and rhBMP-2.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Atrophy Masseter Recovery by Electrical Stimulation Mediated M2-Like Macrophage Polarisation via JAK/PI3K/AKT Pathway.Journal of cachexia, sarcopenia and muscle · 2025Article
- The Effect of Bone Mechanical Stress Caused by Electrical Stimulation-Induced Muscle Contraction on Osteocalcin Secretion.Biology · 2024Article
- Mechanobiology in cellular, molecular, and tissue adaptation.Mechanobiology in medicine · 2023Article
- Evaluation of mandibular trabecular and cortical bone by fractal analysis and radiomorphometric indices in bruxist and non-bruxist patients.BMC oral health · 2023Article
- Effects of whole body vibration on bone properties in growing rats.International biomechanics · 2022Article
- Determinants of muscle power and force as assessed by Jumping Mechanography in rural Indian children.Journal of musculoskeletal & neuronal interactions · 2022Article
- Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal.Frontiers in cell and developmental biology · 2020Article
- Experimental proof that multivariate patterns among muscle attachments (entheses) can reflect repetitive muscle use.Scientific reports · 2019Article
- Assessment of acute bone loading in humans using [European journal of nuclear medicine and molecular imaging · 2019Article
- Functional disuse initiates medullary endosteal micro-architectural impairment in cortical bone characterized by nanoindentation.Journal of bone and mineral metabolism · 2019Article
- Quantitative ultrasound imaging monitoring progressive disuse osteopenia and mechanical stimulation mitigation in calcaneus region through a 90-day bed rest human study.Journal of orthopaedic translation · 2019Article
- Low-Frequency Electrical Stimulation of Denervated Skeletal Muscle Retards Muscle and Trabecular Bone Loss in Aged Rats.International journal of medical sciences · 2019Article
- Efficacy and Safety of Low Frequency Whole-Body Electromyostimulation (WB-EMS) to Improve Health-Related Outcomes in Non-athletic Adults. A Systematic Review.Frontiers in physiology · 2018Article
- Condylar Degradation from Decreased Occlusal Loading following Masticatory Muscle Atrophy.BioMed research international · 2018Article
- Mechanical basis of bone strength: influence of bone material, bone structure and muscle action.Journal of musculoskeletal & neuronal interactions · 2017Review
- Spatial distribution and remodeling of elastic modulus of bone in micro-regime as prediction of early stage osteoporosis.Journal of biomechanics · 2016Article
- Exercise Regulation of Marrow Adipose Tissue.Frontiers in endocrinology · 2016Review
- Dynamic fluid flow induced mechanobiological modulation of in situ osteocyte calcium oscillations.Archives of biochemistry and biophysics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
To identify mechanotransductive signals for combating musculoskeletal deterioration, it is essential to determine the components and mechanisms critical to the anabolic processes of musculoskeletal tissues. It is hypothesized that the interaction between bone and muscle may depend on fluid exchange in these tissues by mechanical loading. It has been shown that intramedullary pressure (ImP) and low-level bone strain induced by muscle stimulation (MS) has the potential to mitigate bone loss induced by disuse osteopenia. Optimized MS signals, i.e., low-intensity and high frequency, may be critical in maintaining bone mass and mitigating muscle atrophy. The objectives for this review are to discuss the potential for MS to induce ImP and strains on bone, to regulate bone adaptation, and to identify optimized stimulation frequency in the loading regimen. The potential for MS to regulate blood and fluid flow will also be discussed. The results suggest that oscillatory MS regulates fluid dynamics with minimal mechanical strain in bone. The response was shown to be dependent on loading frequency, serving as a critical mediator in mitigating bone loss. A specific regimen of dynamic MS may be optimized in vivo to attenuate disuse osteopenia and serve as a biomechanical intervention in the clinical setting.
Indexed as
Identifiers
20190376PMC4961074What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.