ArticleGlycobiology2010
Localization and imaging of sialylated glycosphingolipids in brain tissue sections by MALDI mass spectrometry.
Article in Glycobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 91 citations in OpenAlex.
- Review
- Deciphering mouse brain spatial diversity via glyco-lipidomic mapping.Nature communications · 2024Article
- Lipid Rafts: The Maestros of Normal Brain Development.Biomolecules · 2024Review
- Evaluation of 6 MALDI-Matrices for 10 μm Lipid Imaging and On-Tissue MSn with AP-MALDI-Orbitrap.Journal of the American Society for Mass Spectrometry · 2022Article
- Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging.STAR protocols · 2021Article
- Deciphering the Importance of Glycosphingolipids on Cellular and Molecular Mechanisms Associated with Epithelial-to-Mesenchymal Transition in Cancer.Biomolecules · 2021Review
- Mass Spectrometry Imaging for Glycome in the Brain.Frontiers in neuroanatomy · 2021Review
- Soft Matrix-Assisted Laser Desorption/Ionization for Labile Glycoconjugates.Journal of the American Society for Mass Spectrometry · 2019Article
- MALDI imaging delineates hippocampal glycosphingolipid changes associated with neurotoxin induced proteopathy following neonatal BMAA exposure.Biochimica et biophysica acta. Proteins and proteomics · 2017Article
- Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic Injury.Analytical chemistry · 2017Article
- Imaging mass spectrometry identifies prognostic ganglioside species in rodent intracranial transplants of glioma and medulloblastoma.PloS one · 2017Article
- Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury.Journal of neuroscience methods · 2016Article
- Combination of ESI and MALDI mass spectrometry for qualitative, semi-quantitative and in situ analysis of gangliosides in brain.Scientific reports · 2016Article
- MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- 5-Methoxysalicylic acid matrix for ganglioside analysis with matrix-assisted laser desorption/ionization mass spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- Chronic ethanol consumption profoundly alters regional brain ceramide and sphingomyelin content in rodents.ACS chemical neuroscience · 2015Article
- Matrix coating assisted by an electric field (MCAEF) for enhanced tissue imaging by MALDI-MS.Chemical science · 2015Article
- MALDI-Ion Mobility Mass Spectrometry of Lipids in Negative Ion Mode.Analytical methods : advancing methods and applications · 2014Article
- Imaging mass spectrometry of diversified cardiolipin molecular species in the brain.Analytical chemistry · 2014Article
- Analysis of the lipidome of xenografts using MALDI-IMS and UHPLC-ESI-QTOF.Journal of the American Society for Mass Spectrometry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we describe a simple and efficient method for mapping the distribution and localization of all sialylated sphingoglycolipids present in coronal mouse brain sections using a conventional axial matrix-assisted laser desorption/ionization time of flight. A single scan of a histological tissue section gives a complete profile of ganglioside species without derivatization or labeling. We have developed and tested a new matrix preparation (2,6-dihydroxyacetophenone [DHA]/ammonium sulfate/heptafluorobutyric acid [HFBA]) to maximize the detection of all ganglioside species; the ammonium sulfate limits the formation of salt adducts, while the addition of HFBA increases the stability of DHA in a vacuum, thus facilitating imaging applications. Our results, in both extracted samples and whole tissue sections using negative ion reflectron and linear modes, show differences in localization in several brain regions depending on the sialic acids and the ceramide-associated core gangliosides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.