Trial reportPsychosomatic medicine2010
Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging.
Trial report in Psychosomatic medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- An investigation into the sex dependence of post-reperfusion cardiac mitochondrial function and redox balance in chronically stressed rats.Physiological reports · 2025Article
- The Role of Chronic Stress in the Pathogenesis of Ischemic Heart Disease in Women.Comprehensive Physiology · 2025Review
- Cardiovascular Disease, Genetic Susceptibility, and Risk of Psychiatric Disorders and Suicide Attempt: A Community-Based Matched Cohort Study Based on the UK Biobank.Journal of the American Heart Association · 2024Article
- Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease.Nature cardiovascular research · 2024Article
- Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease.medRxiv : the preprint server for health sciences · 2024Article
- Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging.Neurotrauma reports · 2024Article
- Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment.Neurobiology of aging · 2019Article
- Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood.Neurobiology of aging · 2019Article
- Negative fateful life events in midlife and advanced predicted brain aging.Neurobiology of aging · 2018Article
- Vascular risk factor burden and new-onset depression in the community.Preventive medicine · 2018Article
- Steeper change in body mass across four decades predicts poorer cardiometabolic outcomes at midlife.Obesity (Silver Spring, Md.) · 2017Article
- Association between major depression and type 2 diabetes in midlife: findings from the Screening Across the Lifespan Twin Study.Psychosomatic medicine · 2015Article
- Depression as a risk factor for adverse outcomes in coronary heart disease.BMC medicine · 2013Article
- Genetic Underpinnings of Increased BMI and Its Association With Late Midlife Cognitive Abilities.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions.
methodsWe used a prospective twin study with a 12-year follow-up. In 1992, lifetime diagnosis of depression was assessed in 1159 male-male twins and merged with longitudinal health data from the Vietnam Era Twin Registry Study of Aging. Incident heart disease was defined as having myocardial infarction, heart surgery, or angina at 12-year follow-up when twins were 55.4 years (standard deviation, 2.5 years) of age. Risks for heart disease were computed in a logistic regression model that included comparing twins at different levels of phenotypic expression of depression and varying levels of genetic vulnerability at the same time adjusting for pertinent covariates.
resultsAfter adjusting for sociodemographics, co-occurring psychopathology, smoking, obesity, diabetes, hypertension, and social isolation, twins at high genetic risk and exposed to depression remained at greater risk of developing ischemic heart disease (IHD) (odds ratio, 2.55; 95% confidence interval, 1.44-4.49) compared with those at low genetic risk and without phenotypic expression of depression. Odds ratios suggest that twins at genetic liability but without phenotypic expression were at risk of IHD, but the effect was not statistically significant.
conclusionsA history of depression is a risk factor for incident heart disease after adjusting for numerous covariates. Twins with both high genetic vulnerability and phenotypic expression of depression were at greatest risk of IHD. Trends suggest the genetic contribution to IHD that overlaps with depression may partly explain this association, but studies in larger samples are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.