ArticlePsychosomatic medicine2010
Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall.
Article in Psychosomatic medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Anger, hostility and risk of stroke: a meta-analysis of cohort studies.Journal of neurology · 2019Pooled it
- Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.BMC research notes · 2018Pooled it
- Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS).Journal of clinical medicine · 2022Article
- Perfectionistic cognitions, Interleukin-6, and C-Reactive protein: A test of the perfectionism diathesis stress model.Brain, behavior, & immunity - health · 2021Article
- Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.Translational psychiatry · 2020Article
- Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.SSM - population health · 2019Article
- Prevalence of Depression among Patients with Type 2 Diabetes Mellitus and its associated Clinical Factors.Journal of the ASEAN Federation of Endocrine Societies · 2019Article
- Aggression, Social Stress, and the Immune System in Humans and Animal Models.Frontiers in behavioral neuroscience · 2018Review
- Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.Frontiers in genetics · 2018Article
- Physical activity mediates the association between personality and biomarkers of inflammation.SAGE open medicine · 2018Article
- Design, rationale and feasibility of a multidimensional experimental protocol to study early life stress.Contemporary clinical trials communications · 2017Article
- Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.Psychoneuroendocrinology · 2017Article
- Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.Psychoneuroendocrinology · 2016Article
- Article
- Is there Progress? An Overview of Selecting Biomarker Candidates for Major Depressive Disorder.Frontiers in psychiatry · 2016Review
- Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.Genetic epidemiology · 2015Article
- The ABCs of Trait Anger, Psychological Distress, and Disease Severity in HIV.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2015Article
- Hostility and physiological responses to acute stress in people with type 2 diabetes.Psychosomatic medicine · 2015Article
- Cerebrospinal fluid inflammatory cytokines and aggression in personality disordered subjects.The international journal of neuropsychopharmacology · 2015Article
- Cerebrospinal fluid and plasma C-reactive protein and aggression in personality-disordered subjects: a pilot study.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo examine the effects of depressive symptoms and hostility on changes in C-reactive protein (CRP) and interleukin (IL)-6 in response to an acute laboratory stressor. Depressive symptoms moderate the effect of trait hostility on circulating levels of CRP and IL-6.
methodsThe study included 307 men and 218 women, affording the opportunity to examine moderation by gender. Regression analyses were performed to examine depressive symptoms, hostility ratings, gender, and their interactions as predictors of CRP and IL-6 response to an emotion recall task. Analyses were adjusted for age, race, body mass index, and prerecall task levels of either CRP or IL-6.
resultsThe product term for Depressive Symptoms x Hostility x Gender was not significantly related to CRP nor IL-6 response. However, Depressive Symptoms x Hostility did interact to predict CRP response (p = .002); those with the combination of high symptoms of depression and hostility had the largest CRP response. The Depressive Symptoms x Gender interaction was also a predictor of both CRP (p = .001) and IL-6 (p = .04) response; for each inflammatory marker, depressive symptoms were significantly associated with higher CRP response in women, as compared with men. Hostility did not moderate depressive symptoms, nor gender for IL-6.
conclusionsOur findings extend prior research by suggesting that, broadly speaking, depression is related to inflammatory markers; however, this relationship seems complex. Depression seems to be related to inflammation more strongly among hostile individuals and more strongly among women than among men.
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