ArticleChemical senses2010
PI3Kgamma-dependent signaling in mouse olfactory receptor neurons.
Article in Chemical senses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Identification of genes associated with smell dysfunction in Parkinson's disease.Clinical parkinsonism & related disorders · 2026Article
- Ablation of PI3Kγ in neurons protects mice from diet-induced obesity MASLD and insulin resistance.iScience · 2025Article
- Inhibitory signaling in mammalian olfactory transduction potentially mediated by GαMolecular and cellular neurosciences · 2021Article
- Position Review: Functional Selectivity in Mammalian Olfactory Receptors.Chemical senses · 2020Review
- Phosphoinositide-3-Kinase Is the Primary Mediator of Phosphoinositide-Dependent Inhibition in Mammalian Olfactory Receptor Neurons.Frontiers in cellular neuroscience · 2016Article
- Identification of a Novel Gnao-Mediated Alternate Olfactory Signaling Pathway in Murine OSNs.Frontiers in cellular neuroscience · 2016Article
- Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice.International journal of molecular sciences · 2015Article
- Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells.Cell communication and signaling : CCS · 2015Article
- Effect of knocking down the insulin receptor on mouse rod responses.Scientific reports · 2015Article
- Article
- Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.PloS one · 2014Article
- A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum.Journal of cell science · 2013Article
- Peripheral modulation of smell: fact or fiction?Seminars in cell & developmental biology · 2013Review
- Insulin receptor regulates photoreceptor CNG channel activity.American journal of physiology. Endocrinology and metabolism · 2012Article
- Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Odorant-specific modes of signaling in mammalian olfaction.Chemical senses · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Phosphatidylinositol 3-kinase (PI3K)-dependent signaling couples to receptors for many different ligands in diverse cellular systems. Recent findings suggest that PI3K-dependent signaling also mediates inhibition of odorant responses in rat olfactory receptor neurons (ORNs). Here, we present evidence that murine ORNs show PI3K-dependent calcium responses to odorant stimulation, they express 2 G protein-coupled receptor (GPCR)-activated isoforms of PI3K, PI3Kbeta and PI3Kgamma, and they exhibit odorant-induced PI3K activity. These findings support our use of a transgenic mouse model to begin to investigate the mechanisms underlying PI3K-mediated inhibition of odorant responses in mammalian ORNs. Mice deficient in PI3Kgamma, a class IB PI3K that is activated via GPCRs, lack detectable odorant-induced PI3K activity in their olfactory epithelium and their ORNs are less sensitive to PI3K inhibition. We conclude that odorant-dependent PI3K signaling generalizes to the murine olfactory system and that PI3Kgamma plays a role in mediating inhibition of odorant responses in mammalian ORNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.