ArticleStroke2010
The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm.
Article in Stroke, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7.Stroke · 2014Pooled it
- Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.Neurology · 2013Pooled it
- Mortality and causes of death in the Familial Intracranial Aneurysm study.International journal of stroke : official journal of the International Stroke Society · 2013Trial
- Sex-Dependent Manifestations of Intracranial Aneurysms.Stroke (Hoboken, N.J.) · 2024Article
- Endogenous animal models of intracranial aneurysm development: a review.Neurosurgical review · 2021Review
- Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression.BMC medical genomics · 2021Article
- Exome sequencing reveals a novel variant inJournal of neurointerventional surgery · 2020Article
- Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.Neuromolecular medicine · 2019Review
- Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium.BMC medical genomics · 2019Article
- Methylation of the CDKN2A Gene Increases the Risk of Brain Arteriovenous Malformations.Journal of molecular neuroscience : MN · 2019Article
- Associations among Genetic Variants and Intracranial Aneurysm in a Chinese Population.Yonsei medical journal · 2019Article
- Genome-Wide Association between the 2q33.1 Locus and Intracranial Aneurysm Susceptibility: An Updated Meta-Analysis Including 18,019 Individuals.Journal of clinical medicine · 2019Article
- Potential Therapeutic Strategies for Intracranial Aneurysms Targeting Aneurysm Pathogenesis.Frontiers in neuroscience · 2019Review
- A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling.Journal of genetic counseling · 2017Review
- Affected twins in the familial intracranial aneurysm study.Cerebrovascular diseases (Basel, Switzerland) · 2015Article
- Behavioral profile of unruptured intracranial aneurysms: a systematic review.Annals of clinical and translational neurology · 2014Article
- Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.Stroke · 2012Article
- Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.Human genetics · 2012Article
- Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture.Mediators of inflammation · 2012Review
- Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han population.Acta pharmacologica Sinica · 2010Article
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 3 countries.
Funding
Abstract
background and purposeThe purpose of this study was to replicate the previous association of single nucleotide polymorphisms (SNPs) with risk of intracranial aneurysm (IA) and to examine the relationship of smoking with these variants and the risk of IA.
methodsWhite probands with an IA from families with multiple affected members were identified by 26 clinical centers located throughout North America, New Zealand, and Australia. White control subjects free of stroke and IA were selected by random digit dialing from the Greater Cincinnati population. SNPs previously associated with IA on chromosomes 2, 8, and 9 were genotyped using a TaqMan assay or were included in the Affymetrix 6.0 array that was part of a genomewide association study of 406 IA cases and 392 control subjects. Logistic regression modeling tested whether the association of replicated SNPs with IA was modulated by smoking.
resultsThe strongest evidence of association with IA was found with the 8q SNP rs10958409 (genotypic P=9.2x10(-5); allelic P=1.3x10(-5); OR=1.86, 95% CI: 1.40 to 2.47). We also replicated the association with both SNPs on chromosome 9p, rs1333040 and rs10757278, but were not able to replicate the previously reported association of the 2 SNPs on chromosome 2q. Statistical testing showed a multiplicative relationship between the risk alleles and smoking with regard to the risk of IA.
conclusionsOur data provide complementary evidence that the variants on chromosomes 8q and 9p are associated with IA and that the risk of IA in patients with these variants is greatly increased with cigarette smoking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.