ArticleEndocrinology2010
Uncoupling protein-2 decreases the lipogenic actions of ghrelin.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Acylation, a Conductor of Ghrelin Function in Brain Health and Disease.Frontiers in physiology · 2022Review
- Ghrelin, via corticotropin-releasing factor receptors, reduces glucose uptake and increases lipid content in mouse myoblasts cells.Physiological reports · 2021Article
- The role of acylated ghrelin and unacylated ghrelin in the blood and hypothalamus and their interaction with nonalcoholic fatty liver disease.Iranian journal of basic medical sciences · 2020Article
- Ghrelin forms in the modulation of energy balance and metabolism.Eating and weight disorders : EWD · 2019Review
- Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague-Dawley rats.Molecular and cellular biochemistry · 2018Article
- Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity.BMC complementary and alternative medicine · 2018Article
- Urine and serum ghrelin, sCD80 and sCTLA-4 levels in doxorubicin-induced experimental nephrotic syndrome.International urology and nephrology · 2016Article
- AgRP Neurons Regulate Bone Mass.Cell reports · 2015Article
- Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation.The Journal of endocrinology · 2015Article
- Dohaekseunggi-tang extract inhibits obesity, hyperlipidemia, and hypertension in high-fat diet-induced obese mice.BMC complementary and alternative medicine · 2014Article
- CRF type 2 receptors mediate the metabolic effects of ghrelin in C2C12 cells.Obesity (Silver Spring, Md.) · 2014Article
- Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice.PloS one · 2014Article
- Ghrelin: much more than a hunger hormone.Current opinion in clinical nutrition and metabolic care · 2013Review
- GH and IGF1: roles in energy metabolism of long-living GH mutant mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Uncoupling protein 2 gene polymorphisms are associated with obesity.Cardiovascular diabetology · 2012Article
- Yin and Yang - the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake.Journal of neurogastroenterology and motility · 2012Article
- Ghrelin - a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach.Frontiers in neuroscience · 2012Article
- The ghrelin/GOAT/GHS-R system and energy metabolism.Reviews in endocrine & metabolic disorders · 2011Review
- Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance.Reviews in endocrine & metabolic disorders · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The exact mechanisms through which ghrelin promotes lipogenesis are unknown. Uncoupling protein (UCP)-2 is a mitochondrial protein important in regulating reactive oxygen species; however, recent research shows that it may play an important role fat metabolism. Given that ghrelin increases UCP2 mRNA in white adipose tissue, we examined whether the lipogenic actions of ghrelin are modulated by UCP2 using ucp2(+/+) and ucp2(-/-) mice. Chronic ghrelin treatment either via osmotic minipumps or daily ip injections induced body weight gain in both ucp2(+/+) and ucp2(-/-) mice; however, body weight gain was potentiated in ucp2(-/-) mice. Increased body weight gain was completely due to increased body fat as a result of decreased fat oxidation in ucp2(-/-) mice. Ghrelin treatment of ucp2(-/-) mice resulted in a gene expression profile favoring lipogenesis. In a calorie-restriction model of negative energy balance, ghrelin to ucp2(+/+) mice did not increase body weight; however, ghrelin to ucp2(-/-) mice still induced body weight. These results show that UCP2 plays an important role in fat metabolism by promoting fat oxidation and restricts ghrelin-induced lipogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.