ArticleJournal of the American Society for Mass Spectrometry2010
Mobile protons versus mobile radicals: gas-phase unimolecular chemistry of radical cations of cysteine-containing peptides.
Article in Journal of the American Society for Mass Spectrometry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Competition between Charge- and Radical-Driven Dissociations in the Molecular Radical Cations of Tripeptides.ACS physical chemistry Au · 2026Article
- Understanding the Binding and Structures in Model Complexes of Polypeptides and Cofactors.ACS physical chemistry Au · 2025Article
- Chromophore Optimization in Organometallic Au(III) Cys Arylation of Peptides and Proteins for 266 nm Photoactivation.Analytical chemistry · 2024Article
- w-Type ions formed by electron transfer dissociation of Cys-containing peptides investigated by infrared ion spectroscopy.Journal of mass spectrometry : JMS · 2018Article
- The Reaction of Aminonitriles with Aminothiols: A Way to Thiol-Containing Peptides and Nitrogen Heterocycles in the Primitive Earth Ocean.Life (Basel, Switzerland) · 2018Article
- Online Investigation of Aqueous-Phase Electrochemical Reactions by Desorption Electrospray Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- Gas-phase reactivity of peptide thiyl (RS•), perthiyl (RSS•), and sulfinyl (RSO•) radical ions formed from atmospheric pressure ion/radical reactions.Journal of the American Society for Mass Spectrometry · 2013Article
- Fragmentation chemistry of [Met-Gly]•+, [Gly-Met]•+, and [Met-Met]•+ radical cations.Journal of the American Society for Mass Spectrometry · 2013Article
- Gas-phase peptide sulfinyl radical ions: formation and unimolecular dissociation.Journal of the American Society for Mass Spectrometry · 2012Article
- Electron capture dissociation of hydrogen-deficient peptide radical cations.Journal of the American Society for Mass Spectrometry · 2012Article
- Dissociation chemistry of hydrogen-deficient radical peptide anions.Journal of the American Society for Mass Spectrometry · 2012Article
- Novel Cβ-Cγ bond cleavages of tryptophan-containing peptide radical cations.Journal of the American Society for Mass Spectrometry · 2012Article
- Post-translational modification in the gas phase: mechanism of cysteine S-nitrosylation via ion-molecule reactions.Rapid communications in mass spectrometry : RCM · 2011Article
- Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine.The journal of physical chemistry. B · 2011Article
- Structure and reactivity of the N-acetyl-cysteine radical cation and anion: does radical migration occur?Journal of the American Society for Mass Spectrometry · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A combination of electrospray ionization (ESI), multistage, and high-resolution mass spectrometry experiments are used to examine the gas-phase fragmentation reactions of radical cations of cysteine containing di- and tripeptides. Two different chemical methods were used to form initial populations of radical cations in which the radical sites were located at different positions: (1) sulfur-centered cysteinyl radicals via bond homolysis of protonated S-nitrosocysteine containing peptides; and (2) alpha-carbon backbone-centered radicals via Siu's sequence of reactions (J. Am. Chem. Soc.2008, 130, 7862). Comparison of the fragmentation reactions of these regiospecifically generated radicals suggests that hydrogen atom transfer (HAT) between the alpha C-H of adjacent residues and the cysteinyl radical can occur. In addition, using accurate mass measurements, deuterium labeling, and comparison with an authentic sample, a novel loss of part of the N-terminal cysteine residue was shown to give rise to the protonated, truncated N-formyl peptide (an even-electron x(n) ion). DFT calculations were performed on the radical cation [GCG]*(+) to examine: the relative stabilities of isomers with different radical and protonation sites; the barriers associated with radical migration between four possible radical sites, [G*CG](+), [GC*G](+), [GCG*](+), and [GC(S*)G](+); and for dissociation from these sites to yield b(2)-type ions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.