ArticleSurgery2010
Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury.
Article in Surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 85 citations in OpenAlex.
- New burn model for developing consistent second- and third-degree burn injuries in rats.BMC research notes · 2025Article
- Development of Nanotechnology-Based Drug Delivery Systems for Controlling Clinical Multidrug-ResistantPharmaceutics · 2023Article
- Article
- A Pilot Study on the Effect of Thyme Microemulsion Compared with Antibiotic as Treatment ofVeterinary medicine international · 2022Article
- Dermal Nanoemulsion Treatment Reduces Burn Wound Conversion and Improves Skin Healing in a Porcine Model of Thermal Burn Injury.Journal of burn care & research : official publication of the American Burn Association · 2021Article
- Topical Antiseptic Formulations for Skin and Soft Tissue Infections.Pharmaceutics · 2021Review
- Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment.Nanomaterials (Basel, Switzerland) · 2021Review
- Recent advances in nanotherapeutics for the treatment of burn wounds.Burns & trauma · 2021Review
- Antibacterial potential of essential oils ofIranian journal of microbiology · 2020Article
- Article
- Effect of formulation parameters on pharmacokinetics, pharmacodynamics, and safety of diclofenac nanomedicine.Drug delivery and translational research · 2019Article
- EVALUATION OF EFFECTIVENESS IN A NOVEL WOUND HEALING OINTMENT-CROCODILE OIL BURN OINTMENT.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- Nanoparticles for Control of Biofilms of Acinetobacter Species.Materials (Basel, Switzerland) · 2016Review
- Nanomedicines for Endothelial Disorders.Nano today · 2015Article
- Antibacterial activity of neem nanoemulsion and its toxicity assessment on human lymphocytes in vitro.International journal of nanomedicine · 2015Article
- Antibiotic eluting clay mineral (Laponite®) for wound healing application: an in vitro study.Journal of materials science. Materials in medicine · 2014Article
- Animal models in burn research.Cellular and molecular life sciences : CMLS · 2014Review
- Evaluation of a nisin-eluting nanofiber scaffold to treat Staphylococcus aureus-induced skin infections in mice.Antimicrobial agents and chemotherapy · 2013Article
- Antimicrobial activity of nanoemulsion in combination with cetylpyridinium chloride in multidrug-resistant Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2013Article
- Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens.The Journal of investigative dermatology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNanoemulsions are broadly antimicrobial oil-in-water emulsions containing nanometer-sized droplets stabilized with surfactants. We hypothesize that topical application of a nanoemulsion compound (NB-201) can attenuate burn wound infection. In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and thereby lessen inflammation following thermal injury.
methodsMale Sprague-Dawley rats underwent a 20% total body surface area scald burn to create a partial-thickness burn injury. Animals were resuscitated with Ringer's lactate solution and the wound covered with an occlusive dressing. At 8 hours after injury, the burn wound was inoculated with 1 x 10(6) colony-forming units (CFUs) of Pseudomonas aeruginosa. NB-201, NB-201 placebo, 5% mafenide acetate solution, or 0.9% saline (control) was applied onto the wound at 16 and 24 hours after burn injury. Skin was harvested 32 hours postburn for quantitative wound culture and determination of inflammatory mediators in tissue homogenates.
resultsNB-201 decreased mean bacterial growth in the burn wound by 1,000-fold, with only 13% (3/23) of animals having P. aeruginosa counts greater than 10(5) CFU/g tissue versus 91% (29/32) in the control group (P < .0001). Treatment with NB-201 attenuated neutrophil sequestration in the treatment group as measured by myeloperoxidase assay and by histology. It also significantly decreased levels of proinflammatory cytokines (interleukin [IL]-1beta and IL-6) and the degree of hair follicle cell apoptosis in skin compared to saline-treated controls.
conclusionTopical NB-201 substantially decreased bacterial growth in a partial-thickness burn model. This decrease in the level of wound infection was associated with an attenuation of the local dermal inflammatory response and diminished neutrophil sequestration. NB-201 represents a novel potent antimicrobial and anti-inflammatory treatment for use in burn wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.