ArticleJournal of midwifery & women's health
The long-term effects of prenatal nicotine exposure on neurologic development.
Article in Journal of midwifery & women's health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Nicotine Exposure During Pregnancy and Postnatal Cognitive Outcomes: A Systematic Review and Meta-Analysis.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- The correlation between prenatal maternal active smoking and neurodevelopmental disorders in children: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Psychosocial interventions for supporting women to stop smoking in pregnancy.The Cochrane database of systematic reviews · 2017Pooled it
- Psychosocial interventions for supporting women to stop smoking in pregnancy.The Cochrane database of systematic reviews · 2013Pooled it
- Machine Learning Approaches to Identify Influential Factors of the Comorbid Psychiatric Symptoms and Hypertension Among Rural Adults in Bangladesh: A Cross-Sectional Study.Health science reports · 2026Article
- Article
- Anxiety, Depression, and Emotional Dysregulation Following Prenatal Substance Exposure.Advances in experimental medicine and biology · 2026Review
- Nicotine in e-cigarette aerosol reduces GABA neuron migration via the α7 nicotinic acetylcholine receptor.Scientific reports · 2025Article
- Direct and indirect effects of smoking during pregnancy on child development: The Japan Environment and Children's Study.Scientific reports · 2025Article
- Antioxidant Properties ofCombinatorial chemistry & high throughput screening · 2025Article
- Associations between prenatal exposure to environmental phenols and child neurodevelopment at two years of age in a South African birth cohort.Environmental research · 2025Article
- Tobacco Smoke Exposure in Children and Adolescents: Prevalence, Risk Factors and Co-Morbid Neuropsychiatric Conditions in a US Nationwide Study.Healthcare (Basel, Switzerland) · 2024Article
- Chronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model.Frontiers in pharmacology · 2024Article
- Nicotine and Cytisine Embryotoxicity in the Experimental Zebrafish Model.International journal of molecular sciences · 2023Article
- Prenatal tobacco smoke exposure and risk of brain abnormalities on magnetic resonance imaging at term in infants born very preterm.American journal of obstetrics & gynecology MFM · 2023Article
- Early Postnatal Exposure to Intermittent Hypercapnic Hypoxia (IHH), but Not Nicotine, Decreases Reelin in the Young Piglet Hippocampus.Neurotoxicity research · 2022Article
- The effects of prenatal nicotine and THC E-cigarette exposure on motor development in rats.Psychopharmacology · 2022Article
- Altered Development of Mesencephalic Dopaminergic Neurons in SIDS: New Insights into Understanding Sudden Infant Death Pathogenesis.Biomedicines · 2021Article
- DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure†.Biology of reproduction · 2021Review
- Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A large body of documented evidence has found that smoking during pregnancy is harmful to both the mother and the fetus. Prenatal exposure to nicotine in various forms alters neurologic development in experimental animals and may increase the risk for neurologic conditions in humans. There is a positive association between maternal smoking and sudden infant death syndrome (SIDS); however, the connection between nicotine addiction, depression, attention disorders, and learning and behavior problems in humans is not straightforward. Nicotine's action on the production and function of neurotransmitters makes it a prime suspect in the pathology of these diseases. Nicotine accentuates neurotransmitter function in adults but desensitizes these functions in prenatally exposed infants and children. This desensitization causes an abnormal response throughout the lifespan. Furthermore, nicotine use by adolescents and adults can alleviate some of the symptoms caused by these neurotransmitter problems while they increase the risk for nicotine addiction. Although nicotine replacement drugs are used by pregnant women, there is no clear indication that they improve outcomes during pregnancy, and they may add to the damage that occurs to the developing neurologic system in the fetus. Understanding the effects of nicotine exposure is important in providing safe care for pregnant women, children, and families and for developing appropriate smoking cessation programs during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.