ArticleFree radical biology & medicine2010
Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin.
Article in Free radical biology & medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks.BMC bioinformatics · 2019Article
- Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.International review of cell and molecular biology · 2018Review
- Oxidative stress and redox regulation on hippocampal-dependent cognitive functions.Archives of biochemistry and biophysics · 2015Review
- Delayed administration of alpha-difluoromethylornithine prevents hippocampus-dependent cognitive impairment after single and combined injury in mice.Radiation research · 2014Article
- SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.Antioxidants & redox signaling · 2014Review
- Mitochondrial hydrogen peroxide and defective cholesterol efflux prevent in vitro fertilization by cryopreserved inbred mouse sperm.Biology of reproduction · 2013Article
- The peroxidase activity of mitochondrial superoxide dismutase.Free radical biology & medicine · 2013Article
- Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage.PloS one · 2013Article
- Manganese superoxide dismutase, MnSOD and its mimics.Biochimica et biophysica acta · 2012Review
- Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects.PloS one · 2012Article
- Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.Free radical research · 2011Article
- Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.Free radical biology & medicine · 2011Review
- Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes.Experimental biology and medicine (Maywood, N.J.) · 2011Article
- A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.Anti-cancer agents in medicinal chemistry · 2011Review
- Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.Free radical research · 2011Article
- Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.Anti-cancer agents in medicinal chemistry · 2011Article
- Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.Free radical biology & medicine · 2011Article
- Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts.Free radical biology & medicine · 2010Article
- Modulation of MnSOD in Cancer:Epidemiological and Experimental Evidence.Toxicological research · 2010Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Mn superoxide dismutase (MnSOD) is an important mitochondrial antioxidant enzyme, and elevated MnSOD levels have been shown to reduce tumor growth in part by suppressing cell proliferation. Studies with fibroblasts have shown that increased MnSOD expression prolongs cell cycle transition time in G1/S and favors entrance into the quiescent state. To determine if the same effect occurs during tissue regeneration in vivo, we used a transgenic mouse system with liver-specific MnSOD expression and a partial hepatectomy paradigm to induce synchronized in vivo cell proliferation during liver regeneration. We show in this experimental system that a 2.6-fold increase in MnSOD activity leads to delayed entry into S phase, as measured by reduction in bromodeoxyuridine (BrdU) incorporation and decreased expression of proliferative cell nuclear antigen (PCNA). Thus, compared to control mice with baseline MnSOD levels, transgenic mice with increased MnSOD expression in the liver have 23% fewer BrdU-positive cells and a marked attenuation of PCNA expression. The increase in MnSOD activity also leads to an increase in the mitochondrial form of thioredoxin (thioredoxin 2), but not in several other peroxidases examined, suggesting the importance of thioredoxin 2 in maintaining redox balance in mitochondria with elevated levels of MnSOD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.