Trial reportNeuroscience letters2010
The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men.
Trial report in Neuroscience letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Trial
- Effects of tryptophan depletion and a simulated alcohol binge on impulsivity.Experimental and clinical psychopharmacology · 2015Trial
- A nonhuman primate model of human non-suicidal self-injury: serotonin-transporter genotype-mediated typologies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Mismatches in resident and stranger serotonin transporter genotypes lead to escalated aggression, and the target for aggression is mediated by sex differences in male and female rhesus monkeys (Macaca mulatta).Hormones and behavior · 2022Article
- Article
- Risk-taking in traffic is associated with unhealthy lifestyle: Contribution of aggressiveness and the serotonin transporter genotype.Neuroscience applied · 2022Article
- "Out, out, brief candle! Life's but a walking shadow":Frontiers in psychiatry · 2020Article
- Impact of Polymorphisms in the Serotonin Transporter Gene on Oscillatory Dynamics during Inhibition of Planned Movement in Children.Brain sciences · 2019Article
- INFLUENCE OF THE SEROTONERGIC SYSTEM POLYMORPHISM ON THE EXPRESSION OF DENTAL ANXIETY.Acta clinica Croatica · 2018Article
- Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.Journal of neuroscience research · 2017Review
- Genetic and neural correlates of romantic relationship satisfaction.Social cognitive and affective neuroscience · 2016Article
- Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency.Behavioural brain research · 2015Article
- Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure.Brain research · 2014Article
- Addiction science: Uncovering neurobiological complexity.Neuropharmacology · 2014Review
- Serotonin depletion counteracts sex differences in anxiety-related behaviour in rat.Psychopharmacology · 2013Article
- Genetics of impulsive behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance.Developmental psychology · 2012Article
- Article
- Influence of threat and serotonin transporter genotype on interference effects.Frontiers in psychology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
Reduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion (ATD) or placebo in a randomized, double-blind, parallel group experiment. Impulsive response style was measured on two versions of the Continuous Performance Task (CPT), and calculated using signal detection theory. We observed a dose-dependent effect for the short (S') allele of the 5-HTTLPR on impulsive response style. Individuals who had the S'/S' genotype were more impulsive than individuals with the L/S' genotype. Participants with the L/S' genotype were more impulsive than those with the L/L genotype. ATD increased impulsivity in men, and decreased impulsivity in women. These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental ATD, are both independently and additively, associated with elevated impulsive response style in Caucasian men.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.