ArticleAmerican journal of human genetics2010
Female-to-male breeding ratio in modern humans-an analysis based on historical recombinations.
Article in American journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- The Breeding Sex Ratio Interacts With Demographic History to Shape Comparative Patterns of Variation on the X Chromosome and the Autosomes.Genome biology and evolution · 2025Article
- Comparative Patterns of Variation on the X Chromosome and Autosomes: The Role of the Breeding Sex Ratio.bioRxiv : the preprint server for biology · 2025Article
- Variability in energy expenditure is much greater in males than females.Journal of human evolution · 2022Article
- How much does the unguarded X contribute to sex differences in life span?Evolution letters · 2022Article
- Comparing the Self-Reported Health, Happiness, and Marital Happiness of a Multinational Sample of Consensually Non-Monogamous Adults with Those of the U.S. General Population: Additional Comparisons by Gender, Number of Sexual Partners, Frequency of Sex, and Marital Status.Archives of sexual behavior · 2021Article
- The inference of sex-biased human demography from whole-genome data.PLoS genetics · 2019Article
- Inferring sex-specific demographic history from SNP data.PLoS genetics · 2018Article
- Beyond 2/3 and 1/3: The Complex Signatures of Sex-Biased Admixture on the X Chromosome.Genetics · 2015Article
- Article
- Contrasting X-linked and autosomal diversity across 14 human populations.American journal of human genetics · 2014Article
- Sperm competition in humans: mate guarding behavior negatively correlates with ejaculate quality.PloS one · 2014Article
- Natural selection reduced diversity on human y chromosomes.PLoS genetics · 2014Article
- Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences.Investigative genetics · 2014Article
- Article
- A resolution of the mutation load paradox in humans.Genetics · 2012Article
- Estimators of the human effective sex ratio detect sex biases on different timescales.American journal of human genetics · 2010Article
- Mapping genes that predict treatment outcome in admixed populations.The pharmacogenomics journal · 2010Article
- Can a sex-biased human demography account for the reduced effective population size of chromosome X in non-Africans?Molecular biology and evolution · 2010Article
- Sex-averaged recombination and mutation rates on the X chromosome: a comment on Labuda et al.American journal of human genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Was the past genetic contribution of women and men to the current human population equal? Was polygyny (excess of breeding women) present among hominid lineages? We addressed these questions by measuring the ratio of population recombination rates between the X chromosome and the autosomes, rho(X)/rho(A). The X chromosome recombines only in female meiosis, whereas autosomes undergo crossovers in both sexes; thus, rho(X)/rho(A) reflects the female-to-male breeding ratio, beta. We estimated beta from rho(X)/rho(A) inferred from genomic diversity data and calibrated with recombination rates derived from pedigree data. For the HapMap populations, we obtained beta of 1.4 in the Yoruba from West Africa, 1.3 in Europeans, and 1.1 in East Asian samples. These values are consistent with a high prevalence of monogamy and limited polygyny in human populations. More mutations occur during male meiosis as compared to female meiosis at the rate ratio referred to as alpha. We show that at alpha not equal 1, the divergence rates and genetic diversities of the X chromosome relative to the autosomes are complex functions of both alpha and beta, making their independent estimation difficult. Because our estimator of beta does not require any knowledge of the mutation rates, our approach should allow us to dissociate the effects of alpha and beta on the genetic diversity and divergence rate ratios of the sex chromosomes to the autosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.