ArticleThe journal of physical chemistry. B2010
Adsorption of alpha-synuclein on lipid bilayers: modulating the structure and stability of protein assemblies.
Article in The journal of physical chemistry. B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Order-to-Disorder and Disorder-to-Order Transitions of Proteins upon Binding to Phospholipid Membranes: Common Ground and Dissimilarities.Biomolecules · 2025Review
- Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders.Frontiers in aging neuroscience · 2021Review
- The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson's Diseases.Frontiers in neuroscience · 2019Review
- Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.Acta neuropathologica communications · 2017Article
- Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles.The Journal of biological chemistry · 2016Article
- Low alpha-synuclein levels in the blood are associated with insulin resistance.Scientific reports · 2015Observational
- Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity.Neurobiology of disease · 2015Article
- Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis.Biophysical journal · 2015Article
- Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics.ACS chemical neuroscience · 2013Article
- Exploring the accessible conformations of N-terminal acetylated α-synuclein.FEBS letters · 2013Review
- On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms.ACS chemical neuroscience · 2013Article
- Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway.Cellular and molecular life sciences : CMLS · 2013Article
- Depth of α-synuclein in a bilayer determined by fluorescence, neutron reflectometry, and computation.Biophysical journal · 2012Article
- Biophysics of α-synuclein membrane interactions.Biochimica et biophysica acta · 2012Review
- α-Synuclein-induced tubule formation in lipid bilayers.The journal of physical chemistry. B · 2011Article
- Effects of curvature and composition on α-synuclein binding to lipid vesicles.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The interaction of alpha-synuclein with phospholipid membranes has been examined using supported lipid bilayers and epi-fluorescence microscopy. The membranes contained phosphatidylcholine (PC) and phosphatidic acid (PA), which mix at physiological pH. Upon protein adsorption, the lipids undergo fluid-fluid phase separation into PC-rich and PA-rich regions. The protein preferentially adsorbs to the PA-rich regions. The adsorption and subsequent aggregation of alpha-synuclein was probed by tuning several parameters: the charge on the lipids, the charge on the protein, and the screening environment. Conditions which promoted the greatest extent of adsorption resulted in structurally heterogeneous aggregates, while comparatively homogeneous aggregates were observed under conditions whereby adsorption did not occur as readily. Our observation that different alterations to the system lead to different degrees of aggregation and different aggregate structures poses a challenge for drug discovery. Namely, therapies aimed at neutralizing alpha-synuclein must target a broad range of potentially toxic, membrane-bound assemblies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.