ArticleEuropean journal of applied physiology2010
Myogenic regulatory factor response to resistance exercise volume in skeletal muscle.
Article in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Exercise training to preserve vitality capacity in ageing.Experimental physiology · 2026Review
- Is there a volume saturation point for muscle hypertrophy in resistance-trained individuals? A narrative review.European journal of applied physiology · 2025Review
- Review
- Effects of Acute Loading Induced Fatigability, Acute Serum Hormone Responses and Training Volume to Individual Hypertrophy and Maximal Strength during 10 Weeks of Strength Training.Journal of sports science & medicine · 2023Article
- Novel individualized power training protocol preserves physical function in adult and older mice.GeroScience · 2019Article
- Short-term disuse promotes fatty acid infiltration into skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2018Article
- The Secretory Leukocyte Protease Inhibitor mRNA expression is involved with inflammatory control after downhill exercise in the triceps brachii intermediary head in Wistar rats.Journal of muscle research and cell motility · 2017Article
- Novel single skeletal muscle fiber analysis reveals a fiber type-selective effect of acute exercise on glucose uptake.American journal of physiology. Endocrinology and metabolism · 2016Article
- Influence of exercise intensity on atrophied quadriceps muscle in the rat.Journal of physical therapy science · 2015Article
- Downhill exercise-induced changes in gene expression related with macrophage polarization and myogenic cells in the triceps long head of rats.Inflammation · 2015Article
- Blood flow restricted resistance training attenuates myostatin gene expression in a patient with inclusion body myositis.Biology of sport · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the impact of resistance exercise volume on myoD and myogenin in rodent quadriceps muscle. Six-month-old male Sprague-Dawley rats (316 +/- 2 g) performed either low-volume (LV; 10 sets x 10 contractions) or high-volume (HV; 20 sets x 10 contractions) resistance exercise at 75% one-repetition maximum. Muscles were analyzed for myogenin and myoD mRNA and protein expression 6, 12, 24 and 48 h post-exercise. In red quadriceps (RQ), myogenin mRNA was significantly elevated at 6 h following LV and this response was greater than HV at 6 h, while myogenin protein was significantly increased at 6 and 12 h following LV but only at 12 h following HV (P < 0.05). MyoD mRNA was increased at 6 and 12 h following LV and at 12 h following HV, while myoD protein was slightly decreased (LV; P < 0.05) or unchanged over time (HV). No changes were detected within the white quadriceps muscle. We conclude that acute resistance exercise can activate myogenin and myoD expression levels in RQ, but when exercise volume is doubled these myogenic responses are not proportional but delayed and blunted possibly because of excessive damage/injury. Further work is needed to determine the consequences of these specific myogenic responses on muscle hypertrophy following high-volume resistance exercise training.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.