ArticleMagnetic resonance in medicine2010
Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.
Article in Magnetic resonance in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- A portable ventilator with integrated physiologic monitoring for hyperpolarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Vagal innervation is required for pulmonary function phenotype inAmerican journal of physiology. Lung cellular and molecular physiology · 2017Article
- Using imaging as a biomarker for asthma.The Journal of allergy and clinical immunology · 2017Review
- Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.Magnetic resonance in medicine · 2016Article
- Linking Ventilation Heterogeneity Quantified via Hyperpolarized 3He MRI to Dynamic Lung Mechanics and Airway Hyperresponsiveness.PloS one · 2015Article
- Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI.Academic radiology · 2014Article
- Assessment of regional lung function with multivolume (1)H MR imaging in health and obstructive lung disease: comparison with (3)He MR imaging.Radiology · 2014Article
- Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin.Magnetic resonance in medicine · 2013Article
- Article
- A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs.Concepts in magnetic resonance. Part B, Magnetic resonance engineering · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The capability to use high-resolution (3)He MRI to depict regional ventilation changes and airway narrowing in mice challenged with methacholine (MCh) offers the opportunity to gain new insights into the study of asthma. However, to fully exploit the value of this novel technique, it is important to move beyond visual inspection of the images toward automated and quantitative analysis. To address this gap, we describe a postprocessing approach to create ventilation difference maps to better visualize and quantify regional ventilation changes before and after MCh challenge. We show that difference maps reveal subtle changes in airway caliber, and highlight both focal and diffuse regional alterations in ventilation. Ventilation changes include both hypoventilation and compensatory areas of hyperventilation. The difference maps can be quantified by a histogram plot of the ventilation changes, in which the standard deviation increases with MCh dose (R(2) = 0.89). This method of analysis is shown to be more sensitive than simple threshold-based detection of gross ventilation defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.