ArticleInternational journal of methods in psychiatric research2010
Searching for valid psychiatric phenotypes: discrete latent variable models.
Article in International journal of methods in psychiatric research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial.International journal of geriatric psychiatry · 2012Trial
- LACE-UP: An ensemble machine-learning method for health subtype classification on multidimensional binary data.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2014Article
- Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins.Drug and alcohol dependence · 2011Article
- The clinical utility of personality subtypes in patients with anorexia nervosa.Journal of consulting and clinical psychology · 2011Article
- Incorporating scientific knowledge into phenotype development: penalized latent class regression.Statistics in medicine · 2011Article
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4 authors.
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Abstract
introductionA primary challenge in psychiatric genetics is the lack of a completely validated system of classification for mental disorders. Appropriate statistical methods are needed to empirically derive more homogenous disorder subtypes.
methodsUsing the framework of Robins and Guze's ('Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia', American Journal of Psychiatry, 1970, 126(7), 983-987) five phases, latent variable models to derive and validate diagnostic groups are described. A process of iterative validation is proposed through which refined phenotypes would facilitate research on genetics, pathogenesis, and treatment, which would in turn aid further refinement of disorder definitions.
conclusionsLatent variable methods are useful tools for defining and validating psychiatric phenotypes. Further methodological research should address sample size issues and application to iterative validation.
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