ArticleClinical cardiology2010
Gender differences in the treatment of non-ST-segment elevation myocardial infarction.
Article in Clinical cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Impact of gender on short-term and long-term all-cause mortality in patients with non-ST-segment elevation acute coronary syndromes: a meta-analysis.Internal and emergency medicine · 2018Pooled it
- The efficacy of ticagrelor is maintained in women with acute coronary syndromes participating in the prospective, randomized, PLATelet inhibition and patient Outcomes (PLATO) trial.European heart journal · 2014Trial
- Unequal Relief: Sex Disparities in Opioid Use for Cardiac Chest Pain in the Emergency Department.The western journal of emergency medicine · 2026Observational
- Age and gender disparities in administration of opioid for cardiac chest pain in the emergency department.PloS one · 2025Observational
- Gender differences in treatment strategies among patients ≥80 years old with non-ST-segment elevation myocardial infarction.Journal of thoracic disease · 2019Article
- Medical care of acute myocardial infarction patients in a resource limiting country, Trinidad: a cross-sectional retrospective study.BMC health services research · 2019Article
- Prognostic Differences between Men and Women with Acute Coronary Syndrome. Data from a Brazilian Registry.Arquivos brasileiros de cardiologia · 2018Observational
- Assessing and Modifying Coronary Artery Disease Risk in Women.Current treatment options in cardiovascular medicine · 2017Review
- Sex differences in cardiovascular disease - Impact on care and outcomes.Frontiers in neuroendocrinology · 2017Review
- Gender disparities in red blood cell transfusion in elective surgery: a post hoc multicentre cohort study.BMJ open · 2016Article
- Acute coronary syndromes in women and men.Nature reviews. Cardiology · 2016Review
- Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium.Resuscitation · 2016Article
- Gender differences in therapeutic recommendation after diagnostic coronary angiography: insights from the Coronary Angiography and PCI Registry of the German Society of Cardiology.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Sex differences in the treatment and outcome of patients with acute coronary syndrome after percutaneous coronary intervention: a population-based study.Journal of women's health (2002) · 2014Article
- Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients.Critical pathways in cardiology · 2013Article
- Sex differences in cardiovascular drug-induced adverse reactions causing hospital admissions.British journal of clinical pharmacology · 2012Article
- Disparities in heart failure and other cardiovascular diseases among women.Women's health (London, England) · 2012Review
- Examining sex and gender disparities in total joint arthroplasty.Clinical orthopaedics and related research · 2011Review
- Gender differences in the treatment of non-ST-segment elevation myocardial infarction.Clinical cardiology · 2010Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen are at greater risk for worse outcomes associated with acute coronary syndrome (ACS) than are men. One explanation may be that they tend to be treated less aggressively than men even when more aggressive treatment is warranted. The purpose of this analysis was to assess this issue.
methodsWe used the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation (CRUSADE) Quality Improvement Initiative registry, an observational data collection that began in November 2001, with retrospective data collection from January 2001 to December 2006. A total of 32,888 subjects met the inclusion/exclusion criteria for our study, based on strong biochemical evidence of myocardial infarction and acute onset of typical cardiac chest pain. We stratified subjects into 16 cells for coronary intervention, based on 4 age groups and 4 cardiac catheterization findings (insignificant, 1-vessel disease, 2-vessel disease, 3-vessel disease). We also stratified subjects into 20 cells for medical treatment, based on 4 age groups and 5 medical treatments. In each cell we compared the rate of coronary intervention (coronary artery bypass grafting or percutaneous coronary intervention) or medical treatment (glycoprotein IIb/IIIa inhibitors, aspirin, clopidogrel, beta-blocker, and statins) for men vs women.
resultsMen demonstrated significantly higher rates (P < 0.05) of coronary intervention in 7 of the 16 cells and 9 of the 20 medical treatment cells, compared to no cells in which women had statistically higher rates than men.
conclusionThese findings suggest that men are more likely than women to receive coronary intervention and to be medically treated when presenting with evidence of non-ST-segment myocardial infarction, controlled for age, cardiac catheterization findings, and biochemical evidence of myocardial infarction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.