ReviewCytoskeleton (Hoboken, N.J.)2010
Sensing the mechanical state of the axoneme and integration of Ca2+ signaling by outer arm dynein.
Review in Cytoskeleton (Hoboken, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain.Biophysics and physicobiology · 2023Article
- Structure of a microtubule-bound axonemal dynein.Nature communications · 2021Article
- Molecular evidence for adaptive evolution of olfactory-related genes in cervids.Genes & genomics · 2020Article
- Asymmetries in the cilia ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- The flagellar protein Enkurin is required for mouse sperm motility and for transport through the female reproductive tract.Biology of reproduction · 2018Article
- Ciliary Motility: Regulation of Axonemal Dynein Motors.Cold Spring Harbor perspectives in biology · 2017Review
- Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing.Scientific reports · 2015Article
- Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Article
- A Structural Basis for How Motile Cilia Beat.Bioscience · 2014Article
- Novel thioredoxin-like proteins are components of a protein complex coating the cortical microtubules of Toxoplasma gondii.Eukaryotic cell · 2013Article
- Inactivation of Ca2+-induced ciliary reversal by high-salt extraction in the cilia of Paramecium.Protoplasma · 2013Article
- Integrated control of axonemal dynein AAA(+) motors.Journal of structural biology · 2012Review
- The rate of change in Ca(2+) concentration controls sperm chemotaxis.The Journal of cell biology · 2012Article
- Functional architecture of the outer arm dynein conformational switch.The Journal of biological chemistry · 2012Article
- Strategies for locating the female gamete: the importance of measuring sperm trajectories in three spatial dimensions.Molecular human reproduction · 2011Review
- Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Axonemal dyneins have been demonstrated to monitor the mechanical state of the axoneme and must also alter activity in response to various signaling pathways. The central pair/radial spoke systems are clearly involved in controlling inner dynein arm function; however, the mechanisms by which the outer dynein arm transduces regulatory signals appear quite distinct at the molecular level. In Chlamydomonas, these regulatory components include thioredoxins involved in response to redox changes, molecules that tether the gamma heavy-chain motor unit to the A-tubule of the outer doublet and a Ca(2+)-binding protein that controls the structure of the gamma heavy-chain N-terminal domain. Together, these studies now suggest that the gamma heavy chain acts as a key regulatory node for controlling outer arm function in response to alterations in curvature and ligand binding. Furthermore, they allow us to propose a testable molecular mechanism by which altered Ca(2+) levels might lead to a change in ciliary waveform by controlling whether one heavy chain of outer arm dynein acts as a microtubule translocase or as an ATP-dependent brake that limits the amount of interdoublet sliding.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.