ArticlePflugers Archiv : European journal of physiology2010
Possible mechanisms of sudden cardiac death in top athletes: a basic cardiac electrophysiological point of view.
Article in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Trial
- Multidisciplinary and Personalized Molecular Diagnosis to Solving Sudden Death During Sport.Molecular diagnosis & therapy · 2026Review
- Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis.Biomedicines · 2025Article
- Progranulin, sICAM-1, and sVCAM-1 May Predict an Increased Risk for Ventricular Arrhythmias in Patients with Systemic Sclerosis.International journal of molecular sciences · 2024Article
- Article
- Arrhythmogenic Remodeling in the Failing Heart.Cells · 2021Review
- Electrophysiological Effects of the Transient Receptor Potential Melastatin 4 Channel Inhibitor (4-Chloro-2-(2-chlorophenoxy)acetamido) Benzoic Acid (CBA) in Canine Left Ventricular Cardiomyocytes.International journal of molecular sciences · 2021Article
- Long-Term Endurance Exercise Training Alters Repolarization in a New Rabbit Athlete's Heart Model.Frontiers in physiology · 2021Article
- Increased CaScientific reports · 2020Article
- Altered KCanadian journal of physiology and pharmacology · 2019Article
- Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications.European heart journal · 2019Review
- Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men.PloS one · 2019Article
- Comprehensive review of cardiovascular toxicity of drugs and related agents.Medicinal research reviews · 2018Review
- CaJournal of molecular and cellular cardiology · 2017Article
- Detailed heart rate variability analysis in athletes.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Article
- Increased Short-Term Beat-To-Beat Variability of QT Interval in Patients with Acromegaly.PloS one · 2015Article
- Noninvasive cardiac screening in young athletes with ventricular arrhythmias.The American journal of cardiology · 2013Article
- Sudden cardiac death in low- and middle-income countries.Global heart · 2012Article
- Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve.PloS one · 2012Article
- Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk.British journal of pharmacology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sudden death among athletes is very rare (1:50,000-1:100,000 annually) but it is still 2-4 times more frequent than in the age-matched control population and attracts significant media attention. We propose a mechanism underlying sudden cardiac death in athletes that does not relate to myocardial ischemia but is based on repolarization abnormalities due to potassium channel downregulation and can also be best explained by the concurrent presence of several factors such as cardiac hypertrophy (athlete's heart), and/or hypertrophic cardiomyopathy, increased sympathetic tone, genetic defects, drugs, doping agents, food, or dietary ingredients. These factors together can increase the repolarization inhomogeneity of the heart ("substrate") and an otherwise harmless extrasystole ("trigger") occurring with a very unfortunate timing may sometimes induce life-threatening arrhythmias. The effective and possible prevention of sudden cardiac death requires the development of novel cost effective cardiac electrophysiological screening methods. Athletes identified by these tests as individuals at higher proarrhythmic risk should then be subjected to more costly genetic tests in order to uncover possible underlying genetic causes for alterations in ionic channel structure and/or function.
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