ArticleMolecular and cellular biochemistry2010
E4BP4 is a cardiac survival factor and essential for embryonic heart development.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Differential Regulation of Immune-Related Genes in the Developing Heart.Pediatric cardiology · 2025Article
- Circadian cardiac NADAmerican journal of physiology. Cell physiology · 2022Review
- Circadian REV-ERBs repressNature cardiovascular research · 2022Article
- Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.Nature cell biology · 2020Article
- The STAT3/NFIL3 signaling axis-mediated chemotherapy resistance is reversed by Raddeanin A via inducing apoptosis in choriocarcinoma cells.Journal of cellular physiology · 2018Article
- E4BP4/NFIL3 modulates the epigenetically repressed RAS effector RASSF8 function through histone methyltransferases.The Journal of biological chemistry · 2018Article
- Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes.Cardiovascular diabetology · 2015Observational
- Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation.PloS one · 2015Article
- Identification of cis-regulatory modules encoding temporal dynamics during development.BMC genomics · 2014Article
- Effects of stretch and shortening on gene expression in intact myocardium.Physiological genomics · 2014Article
- The genetic basis for survivorship in coronary artery disease.Frontiers in genetics · 2013Article
- Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease.Journal of clinical bioinformatics · 2012Article
- dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila.PLoS genetics · 2012Article
- E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim.Journal of molecular signaling · 2011Article
- New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond.Discoveries (Craiova, Romania)Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bZIP transcription factor E4BP4, has been demonstrated to be a survival factor in pro-B lymphocytes. GATA factors play important roles in transducing the IL-3 survival signal and transactivating the downstream survival gene, E4BP4. In heart, GATA sites are essential for proper transcription of several cardiac genes, and GATA-4 is a mediator of cardiomyocyte survival. However, the role E4BP4 plays in heart is still poorly understood. In this study, Dot-blot hybridization assays using Dig-labeled RNA probes revealed that the E4BP4 gene was expressed in cardiac tissue from several species including, monkey, dog, rabbit, and human. Western blot analysis showed that the E4BP4 protein was consistently present in all of these four species. Furthermore, immunohistochemistry revealed that the E4BP4 protein was overexpressed in diseased heart tissue in comparison with normal heart tissue. In addition, the overexpression of E4BP4 in vitro activated cell survival signaling pathway of cardiomyocytes. At last, siRNA-mediated knock down of E4BP4 in zebrafish resulted in malformed looping of the embryonic heart tube and decreased heart beating. Based on these results, we conclude that E4BP4 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development.
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