ArticlePsychopharmacology2010
Subchronic nandrolone administration reduces cocaine-induced dopamine and 5-hydroxytryptamine outflow in the rat nucleus accumbens.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of Testosterone on Maintenance of Morphine-induced Conditioned Place Preference: Androgen and μ-opioid Receptor Gene Expressions in PFC and NAc of Rats.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Long-term sugar consumption alters extracellular dopamine and acetylcholine levels in the nucleus accumbens shell.Frontiers in behavioral neuroscience · 2026Article
- Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats.Scientific reports · 2025Article
- Chronic high-dose testosterone impairs economic decision making, but has no effect on memory in male rats.Behavioural processes · 2024Article
- Anabolic androgenic steroid abuse in the United Kingdom: An update.British journal of pharmacology · 2020Review
- Anabolic-androgenic steroid abuse and cognitive impairment: Testosterone IMPAIRS biconditional task performance in male rats.Behavioural brain research · 2020Article
- The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity.Frontiers in behavioral neuroscience · 2018Review
- Defining the Construct of Synthetic Androgen Intoxication: An Application of General Brain Arousal.Frontiers in psychology · 2018Article
- Anabolic-androgenic steroids decrease dendritic spine density in the nucleus accumbens of male rats.Neuroscience · 2016Article
- Anabolic-androgenic steroids and decision making: Probability and effort discounting in male rats.Psychoneuroendocrinology · 2015Article
- Anabolic-androgenic steroids impair set-shifting and reversal learning in male rats.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Article
- The impact of nandrolone decanoate on the central nervous system.Current neuropharmacology · 2015Review
- Effects of anabolic-androgens on brain reward function.Frontiers in neuroscience · 2015Review
- The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression.Trends in neurosciences · 2012Review
- Contributions of serotonin in addiction vulnerability.Neuropharmacology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe abuse of anabolic androgenic steroids (AASs) is not only a problem in the world of sports but is associated with the polydrug use of nonathletes. Investigations of the neurochemical effects of AAS have focused in part on the monoaminergic systems, involving, among other things, the development of dependence. We have previously shown that pretreatment with nandrolone decanoate attenuates dose-dependently the increase in extracellular dopamine (DA) concentration evoked by amphetamine and 3,4-methylenedioyxymethamphetamine in the nucleus accumbens (NAc).
objectivesThe aim of this study was to investigate whether the nandrolone pre-exposure modulates the acute neurochemical and behavioral effects of cocaine in rats and whether the effects are long lasting.
methodsDA, 5-hydroxytryptamine (5-HT), and their metabolites were measured from samples collected from the NAc by microdialysis. The behavior of the animals was recorded.
resultsThe present study demonstrates that five injections of nandrolone (5 and 20 mg/kg) inhibited cocaine-evoked DA and 5-HT outflow in the NAc, locomotor activity (LMA), and stereotyped behavior in experimental animals, and that these effects are seen even after elimination of nandrolone from bloodstream.
conclusionsGiven that accumbal outflow of DA and 5-HT, as well as LMA and stereotyped behavior, is related to gratification of stimulant drugs, this study suggests that nandrolone, at the doses tested, has a significant effect on the pleasurable properties of cocaine. Furthermore, because neurochemical and behavioral responses were still attenuated after a fairly long recovery period, it seems that nandrolone may induce long-lasting changes in the brains of rat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.