ArticlePloS one2010
Influence of genetic background and tissue types on global DNA methylation patterns.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism.BMC cancer · 2020Trial
- Severe traumatic injury is associated with profound changes in DNA methylation.NPJ genomic medicine · 2024Article
- DNA Methylation Carries Signatures of Sublethal Effects Under Thermal Stress in Loggerhead Sea Turtles.Evolutionary applications · 2024Article
- Epigenetics of Trauma Transmission and Fetal Alcohol Spectrum Disorder: What Does the Evidence Support?International journal of environmental research and public health · 2023Review
- A Long Polymorphic GT Microsatellite within a Gene Promoter Mediates Non-Imprinted Allele-Specific DNA Methylation of a CpG Island in a Goldfish Inter-Strain Hybrid.International journal of molecular sciences · 2019Article
- Crosstalk of Genetic Variants, Allele-Specific DNA Methylation, and Environmental Factors for Complex Disease Risk.Frontiers in genetics · 2018Review
- Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.Translational psychiatry · 2017Article
- Insights into genetic susceptibility in the etiology of spontaneous preterm birth.The application of clinical genetics · 2015Review
- Effect of body mass index on global DNA methylation in healthy Korean women.Molecules and cells · 2014Article
- Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer.BMC medical genomics · 2014Article
- Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets.BMC systems biology · 2014Article
- Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients.International journal of medical sciences · 2014Article
- Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero.Environmental health perspectives · 2013Article
- A prospective study of LINE-1DNA methylation and development of adiposity in school-age children.PloS one · 2013Article
- Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight.Epigenetics · 2012Article
- Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children.The Journal of allergy and clinical immunology · 2012Article
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- Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis.PloS one · 2012Article
- DNA methylation: an epigenetic risk factor in preterm birth.Reproductive sciences (Thousand Oaks, Calif.) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However, the effects of genetic background and tissue types on DNA methylation at the genome-wide level have not been characterized extensively. To study the effect of genetic background and tissue types on global DNA methylation, we performed DNA methylation analysis using the Affymetrix 500K SNP array on tumor, adjacent normal tissue, and blood DNA from 30 patients with esophageal squamous cell carcinoma (ESCC). The use of multiple tissues from 30 individuals allowed us to evaluate variation of DNA methylation states across tissues and individuals. Our results demonstrate that blood and esophageal tissues shared similar DNA methylation patterns within the same individual, suggesting an influence of genetic background on DNA methylation. Furthermore, we showed that tissue types are important contributors of DNA methylation states.
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