ArticleClinics (Sao Paulo, Brazil)2010
Fascin expression in colorectal carcinomas.
Article in Clinics (Sao Paulo, Brazil), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis.BMC medicine · 2013Pooled it
- A randomized controlled trial evaluating early versus traditional oral feeding after colorectal surgery.Clinics (Sao Paulo, Brazil) · 2011Trial
- The Relationship between SALL4 and Fascin Expression and the Progression of Colorectal Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Review
- Emerging Role of Fascin-1 in the Pathogenesis, Diagnosis, and Treatment of the Gastrointestinal Cancers.Cancers · 2021Review
- Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?Molecular therapy oncolytics · 2021Review
- MYC leads the way.Small GTPases · 2020Review
- Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.Gynecologic oncology · 2019Article
- Early postoperative oral feeding shortens first time of bowel evacuation and prevents long term hospital stay in patients undergoing elective small intestine anastomosis.Gastroenterology and hepatology from bed to bench · 2019Article
- Fascin expression in urinary bladder urothelial carcinoma correlates with unfavourable prognosis.International journal of clinical and experimental pathology · 2019Article
- Association of Fascin and matrix metalloproteinase-9 expression with poor prognostic parameters in breast carcinoma of Egyptian women.Diagnostic pathology · 2014Article
- Stress-induced cleavage of Myc promotes cancer cell survival.Genes & development · 2014Article
- MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer.British journal of cancer · 2014Article
- Molecular and genetic aspects of oncology and infectology in Clinics.Clinics (Sao Paulo, Brazil) · 2012Article
- Clinicopathological significance of fascin and CD44v6 expression in endometrioid carcinoma.Diagnostic pathology · 2012Article
- Fascin expression in dendritic cells and tumor epithelium in thymoma and thymic carcinoma.Oncology letters · 2011Article
- Early Feeding after Colorectal Surgery in Children: Is it Safe?Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the significance of fascin expression in colorectal carcinoma.
methodsThis is a retrospective study of 167 consecutive, well-documented cases of primary colorectal adenocarcinoma for which archival material of surgical specimens from primary tumor resections were available. We chose a representative tissue sample block and examined fascin expression by immunohistochemistry using a primary antibody against "fascin". We calculated the "immunohistochemical score (IHS)" of fascin for each case, which was calculated from the multiplication of scores for the percentage of stained cells and the staining intensity.
resultsFascin immunoreactivity was observed in 59 (35.3%) of all cases with strong reactivity in 24 (14.4%), moderate reactivity in 25 (14.9%) and weak reactivity in 10 (6.0%) cases. Strong/moderate immunoreactivities were mostly observed in invasive fronts of the tumors or in both invasive and other areas. Fascin immunoreactivity scores were significantly higher in tumors with lymph node metastasis (p:0.002) and advanced stage presentation (p:0.007). There was no relation between fascin expression and age, gender, depth of invasion, distant metastasis or histological grade (p>0.05). There was a higher and statistically significant correlation between fascin immunoreactivity in the invasive borders of tumors and lymph node metastasis (r:0.747, p:0.005). In stage III/IV tumors, two-year survival was 92.2% in tumors without fascin immunoreactivity, and only 60.0% in tumors with a fascin IHS>10 (p:0.003).
conclusionThese findings suggest that fascin is heterogeneously expressed in approximately one third of colorectal carcinomas with a significant association with lymph node metastasis, tumor stage and location. Moreover, these results indicate that fascin may have a role in the lymph node metastasis of colorectal carcinomas.
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