ArticlePLoS biology2010
Genome sequence of the pea aphid Acyrthosiphon pisum.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 511 papers.
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Who cites it
511 citing papers in PubMed, 1,020 citations in OpenAlex.
- Article
- Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- New annotations for three pea aphid genome assemblies allow comparative analyses of duplication and gene family evolution.G3 (Bethesda, Md.) · 2026Article
- Developmental expression of Ap-Vas proteins in aphids and flies reveals their evolutionary roles in insects.Insect molecular biology · 2026Article
- Chromosomal-level genome assembly of minute pirate bug Orius nagaii Yasunaga, 1993 (Hemiptera: Anthocoridae).Scientific data · 2026Article
- A chromosome-level genome assembly of the waterlily aphid Rhopalosiphum nymphaeae Linnaeus.Scientific data · 2026Article
- A chromatin accessibility map of pea aphid brain and embryo identifies tissue-specific regulatory elements.bioRxiv : the preprint server for biology · 2026Article
- Chromosome-level genome assembly of the bird cherry-oat aphid, Rhopalosiphum padi (Hemiptera: Aphididae).Scientific data · 2026Article
- Chromosome-level genome assembly of a citrus and tea insect pest, Aphis aurantii.Scientific data · 2026Article
- Review
- High utility of DNA barcoding for species identification and cryptic diversity in Korean aphids (Hemiptera: Aphididae).Scientific reports · 2026Article
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- Insect immune systems: same same but different but still same.Frontiers in immunology · 2026Review
- RNA Interference of TorsinA inBiochemistry & molecular biology journal · 2026Article
- New potential antimicrobial peptides with mirror-symmetrical structure in fungi and insects.Frontiers in microbiology · 2026Article
- Evaluating the Effect of RNA Interference of X-Box Binding Protein 1 (Biochemistry & molecular biology journal · 2026Article
- Gut bacteria induce heterologous immune priming in Rhodnius prolixus encompassing both humoral and cellular immune responses.PLoS pathogens · 2025Article
- Comprehensive Annotation of Olfactory and Gustatory Receptor Genes and Transposable Elements Revealed Their Evolutionary Dynamics in Aphids.Molecular biology and evolution · 2025Article
- Chromosome-level genome assembly of vetch aphid Megoura crassicauda (Hemiptera: Aphididae).Scientific data · 2025Article
- Characterization of odorant binding and chemosensory protein families in the kissing bug Triatoma infestans: comparative analysis among Heteroptera species.BMC genomics · 2025Article
451 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.
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