ReviewCurrent opinion in cardiology2010
The molecular genetics of congenital heart disease: a review of recent developments.
Review in Current opinion in cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Syndromic Hirschsprung's disease and associated congenital heart disease: a systematic review.Pediatric surgery international · 2015Pooled it
- Article
- miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region.International journal of molecular sciences · 2024Article
- An Assessment of the Therapeutic Landscape for the Treatment of Heart Disease in the RASopathies.Cardiovascular drugs and therapy · 2023Review
- Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines.Cardiovascular drugs and therapy · 2022Article
- Epigenetics in Congenital Heart Disease.Journal of the American Heart Association · 2022Review
- Generation and characterization of a Myh6-driven Cre knockin mouse line.Transgenic research · 2021Article
- The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling.Cell death & disease · 2021Article
- Combined effects of AKT serine/threonine kinase 1 polymorphisms and environment on congenital heart disease risk: A case-control study.Medicine · 2020Article
- Specificity, redundancy and dosage thresholds amongBiology open · 2020Article
- Risk factors of congenital heart diseases: A hospital-based case-control study in Isfahan, Iran.ARYA atherosclerosis · 2020Article
- Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease.Journal of nutrition and metabolism · 2018Review
- Advances in the Study of Heart Development and Disease Using Zebrafish.Journal of cardiovascular development and disease · 2016Article
- Evaluation of regulatory genetic variants in POU5F1 and risk of congenital heart disease in Han Chinese.Scientific reports · 2015Article
- The programming of cardiovascular disease.Journal of developmental origins of health and disease · 2015Review
- A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction.PloS one · 2015Article
- Maternal lifestyle factors in pregnancy and congenital heart defects in offspring: review of the current evidence.Italian journal of pediatrics · 2014Review
- NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans.Cardiovascular research · 2014Article
- Association of aminoacyl-tRNA synthetases gene polymorphisms with the risk of congenital heart disease in the Chinese Han population.PloS one · 2014Article
- A potential relationship among beta-defensins haplotype, SOX7 duplication and cardiac defects.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewOur understanding of the interactions of genes and pathways during heart development continues to expand with our knowledge of the genetic basis of congenital heart disease. Along with the discovery of specific genes that cause lesions, recent research has focused on the interactions of some previously identified genes. This review focuses on the progress made during the last year. RECENT
findingsT-box, NK, and GATA transcription factors have known associations with a variety of syndromic and isolated congenital heart defects. Discovery of novel interactions of GATA and T-box transcription factors highlights the direction of recent research. In addition, the critical yet somewhat redundant roles of nkx2.5 and nkx2.7, along with the interaction of nkx2.7 with tbx20, have been elucidated. The contributions of still other transcription factor classes are being elucidated. Further understanding of 22q11.2 deletion and microduplication syndromes and their genetic interactions has also been studied. Recent work also highlights PTPN11 and NOTCH1 in Noonan syndrome. SUMMARY: The recent developments in the genetics of congenital heart disease are reviewed. In many cases, it is the novel interactions of previously known genes that highlight this year's developments. These interactions will ultimately lead to better understanding of downstream transcriptional or signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.