ArticleArteriosclerosis, thrombosis, and vascular biology2010
ABCA1 gene variants regulate postprandial lipid metabolism in healthy men.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis.Scientific reports · 2021Pooled it
- Associations of the ABCA1 gene polymorphisms with plasma lipid levels: A meta-analysis.Medicine · 2018Pooled it
- Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study.Cardiovascular diabetology · 2016Trial
- ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment.Atherosclerosis · 2014Trial
- Obesity genetic association prospective cohort utilizing single center real-world evidence data.Medicine · 2025Article
- Interaction betweenNutrients · 2023Article
- Role ofJournal of personalized medicine · 2022Review
- Crocin ameliorates atherosclerosis by promoting the reverse cholesterol transport and inhibiting the foam cell formation via regulating PPARγ/LXR-α.Cell cycle (Georgetown, Tex.) · 2022Article
- The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease.International journal of molecular sciences · 2021Review
- Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter.International journal of molecular sciences · 2020Article
- Quantile-dependent expressivity of postprandial lipemia.PloS one · 2020Article
- Impact of 3 Common ABCA1 Gene Polymorphisms on Optimal vs Non-Optimal Lipid Profile in Greek Young Nurses.The open cardiovascular medicine journal · 2014Article
- Article
- Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses.Lipids in health and disease · 2012Article
- Hepatic ABC transporters and triglyceride metabolism.Current opinion in lipidology · 2012Review
- The interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipids.Molecular medicine (Cambridge, Mass.) · 2012Review
- Effects of rs7903146 variation in the Tcf7l2 gene in the lipid metabolism of three different populations.PloS one · 2012Article
- Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism.The Journal of clinical endocrinology and metabolism · 2011Article
- ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses.Lipids in health and disease · 2011Article
- Association of ATP-binding cassette transporter-A1 polymorphism with apolipoprotein AI level in Tehranian population.Journal of genetics · 2011Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveGenetic variants of ABCA1, an ATP-binding cassette (ABC) transporter, have been linked to altered atherosclerosis progression and fasting lipid concentration, mainly high-density lipoproteins and apolipoprotein A1; however, results from different studies have been inconsistent. METHODS AND
resultsTo further characterize the effects of ABCA1 variants in human postprandial lipid metabolism, we studied the influence of 3 single nucleotide polymorphisms (i27943 [rs2575875]; i48168 [rs4149272]; R219K [rs2230806]) in the postprandial lipemia of 88 normolipidemic young men who were given a fatty meal. For i27943 and i48168 single nucleotide polymorphisms, fasting and postprandial values of apolipoprotein A1 were higher and postprandial lipemia was much lower in homozygotes for the major alleles, total triglycerides in plasma, and large triglyceride-rich lipoprotein triglycerides. These persons also showed a higher apolipoprotein A1/apolipoprotein B ratio. Major allele homozygotes for i48168 and i27943 showed additionally higher high-density lipoproteins and lower postprandial apolipoprotein B.
conclusionOur work shows that major allele homozygotes for ABCA1 single nucleotide polymorphisms i27943 and i48168 have a lower postprandial response as compared to minor allele carriers. This finding may further characterize the role of ABCA1 in lipid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.