ArticleNucleic acids research2010
Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HTPharmacological reports : PR · 2023Article
- Article
- Molecular insights into the regulation of constitutive activity by RNA editing of 5HTCell reports · 2022Article
- Review
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021Review
- Article
- RNA Editing and Modifications in Mood Disorders.Genes · 2020Review
- A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations.BMC genomics · 2018Article
- Adar3 Is Involved in Learning and Memory in Mice.Frontiers in neuroscience · 2018Article
- Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.Neuroscience · 2015Article
- A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide.Human molecular genetics · 2014Article
- Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions.Molecular and cellular neurosciences · 2014Article
- Serotonin 2c receptor RNA editing in major depression and suicide.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Article
- Article
- Quantification of adenosine-to-inosine editing of microRNAs using a conventional method.Nature protocols · 2012Article
- Antisense sequencing improves the accuracy and precision of A-to-I editing measurements using the peak height ratio method.BMC research notes · 2012Article
- Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.Current topics in microbiology and immunology · 2012Review
- Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders.PloS one · 2012Article
- Accurate identification of A-to-I RNA editing in human by transcriptome sequencing.Genome research · 2012Article
- Quantitative analysis of 5HT(2C) receptor RNA editing patterns in psychiatric disorders.Neurobiology of disease · 2012Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
RNA editing is a post-transcriptional modification of pre-mRNA that results in increased diversity in transcriptomes and proteomes. It occurs in a wide variety of eukaryotic organisms and in some viruses. One of the most common forms of pre-mRNA editing is A-to-I editing, in which adenosine is deaminated to inosine, which is read as guanosine during translation. This phenomenon has been observed in numerous transcripts, including the mammalian 5-HT(2C) receptor, which can be edited at five distinct sites. Methods used to date to quantify 5-HT(2C) receptor editing are labor-intensive, expensive and provide limited information regarding the relative abundance of 5-HT(2C) receptor editing variants. Here, we present a novel, ultra high-throughput method to quantify 5-HT(2C) receptor editing, compare it to a more conventional method, and use it to assess the effect of a range of genetic and pharmacologic manipulations on 5-HT(2C) editing. We conclude that this new method is powerful and economical, and we provide evidence that alterations in 5-HT(2C) editing appear to be a result of regional changes in brain activity, rather than a mechanism to normalize 5-HT(2C) signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.