ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2010
Effects of age on thermal sensitivity in the rat.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Age and sex drive differential behavioral and neuroimmune phenotypes during postoperative pain.Neurobiology of aging · 2023Article
- A Review of Strain and Sex Differences in Response to Pain and Analgesia in Mice.Comparative medicine · 2019Review
- Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat.Neuroscience · 2015Article
- Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age.PloS one · 2015Article
- Thermal sensitivity across ages and during chronic fentanyl administration in rats.Psychopharmacology · 2014Article
- Effects of morphine on thermal sensitivity in adult and aged rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- The effects of age on pain sensitivity: preclinical studies.Pain medicine (Malden, Mass.) · 2012Review
- Effects of age on thermal sensitivity in the rat.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Age-dependent changes in thermal sensitivity were evaluated with reflex- and operant-based assessment strategies in animals ranging in age from 8 to 32 months. The impact of inflammatory injury on thermal sensitivity was also determined in animals of different ages. The results showed that operant measures of escape behavior are needed to demonstrate significant changes in thermal sensitivity across the life span of female Long-Evans rats. Increased escape from both heat (44.5 degrees C) and cold (1.5 degrees C-15 degrees C) was observed for older animals, with a greater relative increase in sensitivity to cold. Physical performance deficits were demonstrated with aging but were not associated with changes in escape responding. Reflex responding to cold stimulation was impaired in older animals but was also influenced by physical disabilities. Reflex responding to heat was not affected by increasing age. Inflammation induced by formalin injections in the dorsal hindpaw increased thermal sensitivity significantly more in older animals than in their younger counterparts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.