Trial reportJournal of psychiatry & neuroscience : JPN2010
Reduced amygdalar and hippocampal size in adults with generalized social phobia.
Trial report in Journal of psychiatry & neuroscience : JPN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Incidence of anxiety after traumatic brain injury: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- Mnemonic discrimination and social anxiety: the role of state anxiety.Cognition & emotion · 2020Trial
- Nucleus accumbens volume as a predictor of anxiety symptom improvement following CBT and SSRI treatment in two independent samples.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder.Translational psychiatry · 2016Trial
- Brain Ageing in Social Anxiety Disorder: An ENIGMA-Anxiety Mega-Analysis Across 26 International Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Autonomic Readiness for Social Threats in Patients with Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder.BMC psychiatry · 2025Article
- Social fear extinction susceptibility is associated with Microbiota-Gut-Brain axis alterations.Brain, behavior, and immunity · 2024Article
- Algorithm-Based Modular Psychotherapy Alleviates Brain Inflammation in Generalized Anxiety Disorder.Life (Basel, Switzerland) · 2024Article
- Examining the relationship between anxiety and regional brain volumes in the National Alzheimer's Coordinating Center uniform, imaging, and biomarker datasets.Cerebral circulation - cognition and behavior · 2024Article
- The regulative role and mechanism of BNST in anxiety disorder.Frontiers in psychiatry · 2024Review
- Amelioration of pain and anxiety in sleep-deprived rats by intra-amygdala injection of cinnamaldehyde.Sleep medicine: X · 2023Article
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- Article
- Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.Molecular psychiatry · 2023Article
- Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression.Translational psychiatry · 2023Review
- The impact of iron deposition on the fear circuit of the brain in patients with Parkinson's disease and anxiety.Frontiers in aging neuroscience · 2023Article
- Amygdala-driven apnea and the chemoreceptive origin of anxiety.Biological psychology · 2022Review
- Pituitary Volume in Individuals with Social Anxiety Disorder.Psychiatry and clinical psychopharmacology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStructural and functional brain imaging studies suggest abnormalities of the amygdala and hippocampus in posttraumatic stress disorder and major depressive disorder. However, structural brain imaging studies in social phobia are lacking.
methodsIn total, 24 patients with generalized social phobia (GSP) and 24 healthy controls underwent 3-dimensional structural magnetic resonance imaging of the amygdala and hippocampus and a clinical investigation.
resultsCompared with controls, GSP patients had significantly reduced amygdalar (13%) and hippocampal (8%) size. The reduction in the size of the amygdala was statistically significant for men but not women. Smaller right-sided hippocampal volumes of GSP patients were significantly related to stronger disorder severity. LIMITATIONS: Our sample included only patients with the generalized subtype of social phobia. Because we excluded patients with comorbid depression, our sample may not be representative.
conclusionWe report for the first time volumetric results in patients with GSP. Future assessment of these patients will clarify whether these changes are reversed after successful treatment and whether they predict treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.