ReviewJournal of psychiatry & neuroscience : JPN2010
Does neuroimaging research examining the pathophysiology of posttraumatic stress disorder require medication-free patients?
Review in Journal of psychiatry & neuroscience : JPN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Transcutaneous vagal nerve stimulation modulates stress-induced plasma ghrelin levels: A double-blind, randomized, sham-controlled trial.Journal of affective disorders · 2023Trial
- Interindividual differences in stress sensitivity: basal and stress-induced cortisol levels differentially predict neural vigilance processing under stress.Social cognitive and affective neuroscience · 2016Trial
- Increased anterior cingulate cortex and hippocampus activation in Complex PTSD during encoding of negative words.Social cognitive and affective neuroscience · 2013Trial
- Neuroimaging in post-traumatic stress disorder: a narrative review.Archives of medical science : AMS · 2025Article
- Grandmotherhood is associated with reduced OXTR DNA methylation.Psychoneuroendocrinology · 2024Article
- A comparison of the functional connectome in mild traumatic brain injury and post-traumatic stress disorder.Human brain mapping · 2023Article
- Sex differences in brain activation patterns with mental stress in patients with coronary artery disease.Biology of sex differences · 2019Article
- Gray Matter Alterations Associated With Dissociation in Female Survivors of Childhood Trauma.Frontiers in psychology · 2019Article
- The cerebellum after trauma: Resting-state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype.Human brain mapping · 2018Article
- Resting-state functional connectivity of the bed nucleus of the stria terminalis in post-traumatic stress disorder and its dissociative subtype.Human brain mapping · 2018Article
- The enemy in the mirror: self-perception-induced stress results in dissociation of psychological and physiological responses in patients with dissociative disorder.European journal of psychotraumatology · 2018Article
- Contrasting Effects of Posttraumatic Stress Disorder and Mild Traumatic Brain Injury on the Whole-Brain Resting-State Network: A Magnetoencephalography Study.Brain connectivity · 2017Article
- Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity.Journal of psychiatric research · 2016Article
- Abnormal functional architecture of amygdala-centered networks in adolescent posttraumatic stress disorder.Human brain mapping · 2016Article
- Anatomical and functional connectivity in the default mode network of post-traumatic stress disorder patients after civilian and military-related trauma.Human brain mapping · 2016Article
- Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.Translational psychiatry · 2015Article
- Bi-Directional Tuning of Amygdala Sensitivity in Combat Veterans Investigated with fMRI.PloS one · 2015Article
- Neural circuits in anxiety and stress disorders: a focused review.Therapeutics and clinical risk management · 2015Review
- Colour or shape: examination of neural processes underlying mental flexibility in posttraumatic stress disorder.Translational psychiatry · 2014Article
- Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
Abstract
backgroundIn an attempt to avoid unknown influence, most neuroimaging studies examining the pathophysiology of posttraumatic stress disorder (PTSD) exclude patients taking medications. Here we review the empirical evidence for relevant medications having a confounding effect on task performance or cerebral blood flow (CBF) in this population. The evidence for potentially confounding effects of psychotherapy in PTSD are also discussed.
methodsThe literature that we reviewed was obtained through a PubMed search from 1980 to 2009 using the search terms posttraumatic stress disorder, PTSD, psychotropic medications, neuroimaging, functional magnetic resonance imaging, positron emission tomography, cerebral blood flow, CBF, serotonin-specific reuptake blocker, benzodiazepine, ketamine, methamphetamine, lamotrigine and atypical antipsychotic agents.
resultsThe empirical evidence for relevant medications having a confounding effect on task performance or CBF in relevant areas remains sparse for most psychotropic medications among patients with PTSD. However, considerable evidence is accumulating for 2 of the most commonly prescribed medication classes (serotonin-specific reuptake inhibitors and benzodiazepines) in healthy controls. Compelling data for the potentially confounding effects on brain areas relevant to PTSD for psychotherapeutic interventions are also accumulating.
conclusionNeuroimaging studies examining the pathophysiology of PTSD should ideally recruit both medicated (assuming that the medication treatment has not resulted in the remission of symptoms) and unmedicated participants, to allow the findings to be generalized with greater confidence to the entire population of patients with PTSD. More research is needed into the independent effects of medications on task performance and CBF in regions of interest in PTSD. Neuroimaging studies should also take into account whether patients are currently engaged in psychotherapeutic treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.