Evidence map›Paper›PMID 20184664›Full record

ReviewJournal of cellular and molecular medicine2010

Functions of ICC-like cells in the urinary tract and male genital organs.

Hikaru Hashitani, Richard J Lang

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Telocytes and interstitial cells of Cajal in the biliary system.Journal of cellular and molecular medicine · 2018
    Review
  7. Combination of Luteolin and Solifenacin Improves Urinary Dysfunction Induced by Diabetic Cystopathy in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  8. Article
  9. Calcium Signaling in Interstitial Cells: Focus on Telocytes.International journal of molecular sciences · 2017
    Review
  10. Role of prostatic interstitial cells in prostate motility.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2017
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. GLI3 repressor controls functional development of the mouse ureter.The Journal of clinical investigation · 2011
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Hikaru HashitaniDepartment of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Richard J Lang
Monash University · AUNagoya City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interstitial cells of Cajal (ICC)-like cells (ICC-LCs) have been identified in many regions of the urinary tract and male genital organs by immunohistochemical studies and electron microscopy. ICC-LCs are characterized by their spontaneous electrical and Ca(2+) signalling and the cellular mechanisms of their generation have been extensively investigated. Spontaneous activity in ICC-LCs rises from the release of internally stored Ca(2+) and the opening of Ca(2+)-activated Cl(-) channels to generate spontaneous transient depolarizations (STDs) in a manner not fundamentally dependent on Ca(2+) influx through L-type voltage-dependent Ca(2+) channels. Since urogenital ICC-LCs have been identified by their immunoreactivity to Kit (CD117) antibodies, the often-used specific marker for ICC in the gastrointestinal tract, their functions have been thought likely to be similar. Thus ICC-LCs in the urogenital tract might be expected to act as either electrical pacemaker cells to drive the smooth muscle wall or as intermediaries in neuromuscular transmission. However, present knowledge of the functions of ICC-LCs suggests that their functions are not so predetermined, that their functions may be very region specific, particularly under pathological conditions. In this review, we summarize recent advances in our understanding of the location and function of ICC-LCs in various organs of the urogenital system. We also discuss several unsolved issues regarding the identification, properties and functions of ICC-LCs in various urogenital regions in health and disease.

Indexed as

AnimalsGenitalia, MaleHumansInterstitial Cells of CajalMaleOrgan SpecificityUrinary Tract

Identifiers

PMID20184664
PMCPMC3828839
OpenAlexW2082446065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.