ArticleJournal of cellular and molecular medicine2011
Conditional TGF-β1 treatment increases stem cell-like cell population in myoblasts.
Article in Journal of cellular and molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Histamine deficiency delays ischaemic skeletal muscle regeneration via inducing aberrant inflammatory responses and repressing myoblast proliferation.Journal of cellular and molecular medicine · 2019Article
- PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification.Journal of tissue engineering and regenerative medicine · 2018Article
- Functional Neuronal Differentiation of Injury-Induced Muscle-Derived Stem Cell-Like Cells with Therapeutic Implications.Scientific reports · 2017Article
- Defining the Balance between Regeneration and Pathological Ossification in Skeletal Muscle Following Traumatic Injury.Frontiers in physiology · 2017Review
- Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.Human molecular genetics · 2014Article
- Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α.Human molecular genetics · 2013Article
- The origin and fate of muscle satellite cells.Stem cell reviews and reports · 2012Review
- Effects of transforming growth factor-beta (TGF-β1) on satellite cell activation and survival during oxidative stress.Journal of muscle research and cell motility · 2011Article
- Slow-adhering stem cells derived from injured skeletal muscle have improved regenerative capacity.The American journal of pathology · 2011Article
- Study of muscle cell dedifferentiation after skeletal muscle injury of mice with a Cre-Lox system.PloS one · 2011Article
- Relaxin regulates MMP expression and promotes satellite cell mobilization during muscle healing in both young and aged mice.The American journal of pathology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The limitation in successfully acquiring large populations of stem cell has impeded their application. A new method based on the dedifferentiation of adult somatic cells to generate induced multipotent stem cells would allow us to obtain a large amount of autologous stem cells for regenerative medicine. The current work was proposed to induce a sub-population of cells with characteristics of muscle stem cells from myoblasts through conditional treatment of transforming growth factor (TGF)-β(1) . Our results show that a lower concentration of TGF-β(1) is able to promote C2C12 myoblasts to express stem cell markers as well as to repress myogenic proteins, which involves a mechanism of dedifferentiation. Moreover, TGF-β(1) treatment promoted the proliferation-arrested C2C12 myoblasts to re-enter the S-phase. We also investigated the multi-differentiation potentials of the dedifferentiated cells. TGF-β(1) pre-treated C2C12 myoblasts were implanted into mice to repair dystrophic skeletal muscle or injured bone. In addition to the C2C12 myoblasts, similar effects of TGF-β(1) were also observed in the primary myoblasts of mice. Our results suggest that TGF-β(1) is effective as a molecular trigger for the dedifferentiation of skeletal muscle myoblasts and could be used to generate a large pool of progenitor cells that collectively behave as multipotent stem cell-like cells for regenerative medicine applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.