ReviewAnti-cancer agents in medicinal chemistry2010
Gliomagenesis and the use of neural stem cells in brain tumor treatment.
Review in Anti-cancer agents in medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRα neurogenic pathway.Neuro-oncology · 2023Article
- Imaging Spectrum of the Developing Glioblastoma: A Cross-Sectional Observation Study.Current oncology (Toronto, Ont.) · 2023Observational
- Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma.Frontiers in molecular neuroscience · 2022Review
- STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma.Oncology letters · 2020Article
- Differentiation of Human Mesenchymal Stem Cells towards Neuronal Lineage: Clinical Trials in Nervous System Disorders.Biomolecules & therapeutics · 2020Review
- The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells.Oncotarget · 2017Article
- Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model.Stem cells translational medicine · 2017Article
- Early-Stage Glioblastomas: MR Imaging-Based Classification and Imaging Evidence of Progressive Growth.AJNR. American journal of neuroradiology · 2017Article
- Article
- Synchronous multicentric glioblastoma with PNET and O subtypes: Possible pathogenesis.Surgical neurology international · 2014Article
- Identification of aberrant microRNA expression pattern in pediatric gliomas by microarray.Diagnostic pathology · 2013Article
- Subventricular zone localized irradiation affects the generation of proliferating neural precursor cells and the migration of neuroblasts.Stem cells (Dayton, Ohio) · 2012Article
- Cancer-initiating enriched cell lines from human glioblastoma: preparing for drug discovery assays.Stem cell reviews and reports · 2012Review
- Contact and encirclement of glioma cells in vitro is an intrinsic behavior of a clonal human neural stem cell line.PloS one · 2012Article
- Neurotransplantation: lux et veritas, fiction or reality?Journal of neurosurgical sciences · 2011Review
- Using living cells to transport therapeutic genes for cancer treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2011Review
- The role of stem cells in tumor targeting and growth suppression of gliomas.Biologics : targets & therapy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The role of neural stem cells (NSCs) in both the physiological and pathological processes in the brain has been refined through recent studies within the neuro-oncological field. Alterations in NSC regulatory mechanisms may be fundamental for the development and progression of malignant gliomas. A subpopulation of cells within the tumor known as brain tumor stem cells (BTSCs) have been shown to share key properties with NSCs. The BTSC hypothesis has significantly contributed to a potential understanding as to why brain tumors hold such dismal prognosis. On the other hand, the normal NSCs possess the capacity to migrate extensively towards the tumor bulk as well as to lingering neoplastic regions of the brain. The tropism of NSCs towards brain tumors may provide an additional tool for the treatment of brain cancer. The creation of potential therapies through the use of NSCs has been studied and includes the delivery of gene products to specific locations of the central nervous system selectively targeting malignant brain tumor cells and maximizing the efficiency of their delivery. Here, the proposed mechanisms of how brain tumors emerge, the molecular pathways interrupted in NSC pathogenesis and the most recent preclinical results in the use of NSCs for glioma treatment are reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.