ArticleJournal of the American Chemical Society2010
Modular synthesis of biodegradable diblock copolymers for designing functional polymersomes.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Targeting and Specific Activation of Antigen-Presenting Cells by Endogenous Antigen-Loaded Nanoparticles Elicits Tumor-Specific Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Article
- Micellization of Photo-Responsive Block Copolymers.Polymers · 2017Review
- Photoresponsive nanoparticles for drug delivery.Nano today · 2015Article
- Caging metal ions with visible light-responsive nanopolymersomes.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Polymersome-based drug-delivery strategies for cancer therapeutics.Therapeutic delivery · 2015Review
- Elucidation of adhesion-dependent spontaneous apoptosis in macrophages using phase separated PEG/polyurethane films.Acta biomaterialia · 2013Article
- Gd-based macromolecules and nanoparticles as magnetic resonance contrast agents for molecular imaging.Current topics in medicinal chemistry · 2013Review
- Student award for outstanding research winner in the Ph.D. category for the 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012: synthesis and application of photodegradable microspheres for spatiotemporal control of protein delivery.Journal of biomedical materials research. Part A · 2012Article
- Sensing membrane stress with near IR-emissive porphyrins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells.Journal of pharmaceuticsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Polymer vesicles, or polymersomes, are promising candidates for applications in drug delivery and tissue imaging. While a vast variety of polymers have been explored for their ability to assemble into polymersomes, relatively little research on the functionalization of these polymers has been reported. We present here a novel route for the synthesis of poly(caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) diblock copolymers that allows for the insertion of functional groups at the block junctions and the assembly of functional membranes. This modular synthesis has been developed on the basis of solid-phase peptide synthesis techniques and is accomplished through the formation of two peptide bonds, one between an amine-terminated PEG and the carboxyl moiety of the functional group and the other between the functional group amine and a carboxy-terminated PCL. As a demonstration of the potential utility of the resulting vesicles, we incorporated two different amino acid functional groups at the junction. 2-Nitrophenylalanine was utilized to create UV-responsive membranes in which the vesicles were destabilized and released encapsulated contents upon irradiation. A fluorescein-conjugated lysine was also utilized to create stable fluorescent membranes in which the fluorescence was built into the polymer. This method should contribute to our ability to further develop smart, functional membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.