ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2010
Comparison of the prophylactic effect of silymarin and deferoxamine on iron overload-induced hepatotoxicity in rat.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 39 citations in OpenAlex.
- Hesperidin alleviated D-GalN/LPS induced acute liver injury in mice: insights into gut microbiota and the Nrf2/Keap1 pathway.Frontiers in microbiology · 2025Article
- The role of ferritin and iron dextran in exacerbating preeclampsia in an L-NAME-treated rat model.Annals of translational medicine · 2022Article
- Effects of silybin supplementation on nutrient digestibility, hematological parameters, liver function indices, and liver-specific mi-RNA concentration in dogs.BMC veterinary research · 2021Article
- Preparation and Evaluation of Silymarin-Loaded Solid Eutectic for Enhanced Anti-Inflammatory, Hepatoprotective Effect:Oxidative medicine and cellular longevity · 2021Article
- Iron overload reduces synthesis and elimination of bile acids in rat liver.Scientific reports · 2019Article
- Cold storage of porcine hepatocyte spheroids for spheroid bioartificial liver.Xenotransplantation · 2019Article
- Green synthesis of safe zero valent iron nanoparticles byRSC advances · 2018Article
- Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver.Experimental and therapeutic medicine · 2017Article
- Protective effect of silymarin against chemical-induced cardiotoxicity.Iranian journal of basic medical sciences · 2016Review
- Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015.Advances in pharmacological sciences · 2016Review
- Antioxidants in liver health.World journal of gastrointestinal pharmacology and therapeutics · 2015Review
- Re: "Protective Role of Silymarin and Deferoxamine against Iron Dextran-Induced Renal Iron Deposition in Male Rats," and "Co-Administration of Silymarin and Deferoxamine against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model".International journal of preventive medicine · 2014Article
- Co-Administration of Silymarin and Deferoxamine against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model.International journal of preventive medicine · 2014Article
- Protective Role of Silymarin and Deferoxamine Against Iron Dextran-induced Renal Iron Deposition in Male Rats.International journal of preventive medicine · 2013Article
- Comparison of the effect of vanadium and deferoxamine on acetaminophen toxicity in rats.Indian journal of pharmacology · 2011Article
- Intraperitoneal Administration of Silymarin Protects End Organs from Multivisceral Ischemia/Reperfusion Injury in a Rat Model.Brazilian journal of cardiovascular surgeryArticle
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In pathologic conditions or poisoning states, iron overload can affect different tissues including liver. In this study, the prophylactic effect of deferoxamine and silymarin was compared in decreasing experimental iron-overload-induced hepatotoxicity in rats. The study was done in six groups of rats, which received drugs q2 days for 2 weeks. The rats in groups 1 to 6 received drugs, respectively: normal saline, iron dextran, iron dextran + deferoxamine (intraperitoneally), iron dextran + silymarin (orally), iron dextran + silymarin (intraperitoneally), and iron dextran + deferoxamine (intraperitoneally) + silymarin (intraperitoneally). At the end of the study, blood was collected, and serum was separated for laboratory tests. The liver of rats was separated for iron measuring and tissue processing. The serum iron concentration and the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were determined. The numbers of necrotic hepatocytes were counted as quantity index tissue injury in light microscopic examination. The mean of serum and liver iron in group 2 was significantly greater than group 1. Liver iron was significantly decreased in other groups except group 4. Also serum iron was decreased in groups 3 to 6 compared to group 2 (nearly 400%). ALT activity in group 3 and AST activity in group 5 were significantly lesser than in other groups. The mean of necrotic hepatocytes in group 2 was significantly increased in comparison to group 1. This elevation was significantly prevented by deferoxamine and silymarin. The result of the present study shows that silymarin has a protective effect similar to deferoxamine on iron overload-induced hepatotoxicity.
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