ArticlePathology oncology research : POR2010
Reduced beta-catenin expression is associated with good prognosis in Astrocytoma.
Article in Pathology oncology research : POR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Integrated analysis of MYC expression, 8q24.21 copy number, and recurrence patterns in astrocytoma, IDH-mutant.Brain tumor pathology · 2025Article
- Down-regulation of 14-3-3zeta reduces proliferation and increases apoptosis in human glioblastoma.Cancer gene therapy · 2020Article
- Article
- Biological Functions of TNKS1 and Its Relationship with Wnt/β-Catenin Pathway in Astrocytoma.OncoTargets and therapy · 2019Article
- Signaling pathways and mesenchymal transition in pediatric high-grade glioma.Cellular and molecular life sciences : CMLS · 2018Review
- Combination of AQP1 and β-catenin expression is an independent prognosis factor in astrocytoma patients.Oncotarget · 2017Article
- Suppression Of β-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.Theranostics · 2017Article
- Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells.Journal of neuropathology and experimental neurology · 2015Article
- Article
- Prognostic significance of astrocyte elevated gene-1 in human astrocytomas.International journal of clinical and experimental pathology · 2014Article
- Increased β-catenin/Tcf signaling in pilocytic astrocytomas: a comparative study to distinguish pilocytic astrocytomas from low-grade diffuse astrocytomas.Neurochemical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the expression of beta-catenin in astrocytoma, and the clinical relevance and prognostic significance of the expression of beta-catenin was also analyzed. Immunohistochemistry was performed on 63 resected astrocytoma tumor specimens to detect the expression of beta-catenin. The correlation between the results of immuoexpression and the clinicopathologic parameters and patient survival was processed statistically. In 63 samples of astrocytoma, 36 cases were immunoreactive for beta-catenin at cytoplasm, ten cases of astrocytoma were immunoreactive at cytomembrane, and four cases of astrocytoma were stained for beta-catenin at nucleus. Spearman analysis showed that the distribution of beta-catenin was not correlated with the grades of astrocytoma. However, the expression profiles were correlated with the patient's 2-year survival, but not correlated with the grades, tumor size, sex, age, or tumor location. Patients with low beta-catenin expression levels tended to be associated with a better prognosis than those who with high levels (p = 0.042). Our results suggest that beta-catenin is useful for the prognosis evaluation of astrocytoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.