ReviewCell stress & chaperones2010
Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract.
Review in Cell stress & chaperones, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- The association between vaginal microbiota and female infertility: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2020Pooled it
- Preconception Chlamydia trachomatis seropositivity and fecundability, live birth, and adverse pregnancy outcomes.Fertility and sterility · 2025Trial
- Immunomodulatory and antimicrobial actions of extracellular vesicles in vaginal infections: implications for female infertility.Molecular biology reports · 2026Review
- Current methods and mechanisms for animal models of pelvic inflammatory disease: a review.Frontiers in veterinary science · 2026Review
- Global, Regional, and National Burden of Female Infertility Attributable to Chlamydia Infections, 1990-2023: An Analysis Based on the Global Burden of Disease Study 2023.International journal of women's health · 2026Article
- Role of IFN-γ from Different Immune Cells inMicroorganisms · 2025Review
- Global burden of female infertility attributable to sexually transmitted infections and maternal sepsis: 1990-2021 and projections to 2050.Scientific reports · 2025Article
- Fascinating Molecular and Immune Escape Mechanisms in the Treatment of STIs (Syphilis, Gonorrhea, Chlamydia, and Herpes Simplex).International journal of molecular sciences · 2022Review
- Female urogenital chlamydia: Epidemiology, chlamydia on pregnancy, current diagnosis, and treatment.Annals of medicine and surgery (2012) · 2022Review
- Assisted Reproductive Technology Treatment, the Catalyst to Amplify the Effect of Maternal Infertility on Preterm Birth.Frontiers in endocrinology · 2022Article
- RevisitingMicroorganisms · 2021Article
- The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.International journal of molecular sciences · 2021Review
- Antibodies toLupus science & medicine · 2018Article
- Chlamydia trachomatis: the Persistent Pathogen.Clinical and vaccine immunology : CVI · 2017Review
- Considerations for the rational design of a Chlamydia vaccine.Human vaccines & immunotherapeutics · 2017Review
- Sexually transmitted diseases and infertility.American journal of obstetrics and gynecology · 2017Review
- Heat shock proteins: a therapeutic target worth to consider.Veterinary world · 2015Review
- Why sexually transmitted infections tend to cause infertility: an evolutionary hypothesis.PLoS pathogens · 2014Article
- Prevalence and diagnostic significance of specific IgA and anti-heat shock protein 60 Chlamydia trachomatis antibodies in subfertile women.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- B-cell epitopes in GroEL of Francisella tularensis.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia trachomatis is an obligate intracellular bacterium that infects chiefly urogenital and ocular epithelial cells. In some infected women the microorganism migrates to the upper reproductive tract resulting in a chronic, but asymptomatic, infection. The immune response to this infection, production of interferon-gamma and pro-inflammatory cytokines, results in interruption of chlamydial intracellular replication. However, the Chlamydia remains viable and enters into a persistent state. In this form, most chlamydial genes are inactive. An exception is the gene coding for the 60 kDa heat shock protein (hsp60), which is synthesized in increased amounts and is released into the extracellular milieu. The chronic release of chlamydial hsp60 induces a local pro-inflammatory immune response in fallopian tube epithelia and results in scar formation and tubal occlusion. In addition, long-term exposure of the maternal immune system to the chlamydial hsp60 eventually results in the release of tolerance and generation of an immune response that recognizes regions of the chlamydial hsp60 that are also present in the human hsp60. Production of cross-reacting antibodies and cell-mediated immunity to the human hsp60 is detrimental to subsequent pregnancy outcome and may also possibly increase susceptibility to atherosclerosis, autoimmune disorders, or malignancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.