ArticleMetabolic brain disease2010
Central pontine myelinolysis: historical and mechanistic considerations.
Article in Metabolic brain disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Osmotic demyelination as a complication of hyponatremia correction: a systematic review.Jornal brasileiro de nefrologiaPooled it
- Trial
- Contribution of Myelin Damage to White Matter Changes in Osmotic Demyelination Syndrome.Diagnostics (Basel, Switzerland) · 2026Article
- Imaging Findings and Toxicological Mechanisms of Nervous System Injury Caused by Diquat.Molecular neurobiology · 2024Review
- Cerebral white matter injury in haemodialysis patients: a cross-sectional tract-based spatial statistics and fixel-based analysis.Clinical kidney journal · 2024Article
- Genetic and pathophysiological insights from autopsied patient with primary familial brain calcification: novel MYORG variants and astrocytic implications.Acta neuropathologica communications · 2024Article
- Locked-in syndrome after central pontine myelinolysis, an outstanding outcome of two patients.Annals of clinical and translational neurology · 2024Article
- Article
- Unusual progression of osmotic demyelination after liver transplantation on MRI brain.Radiology case reports · 2022Article
- The Changing Face of Osmotic Demyelination Syndrome: A Retrospective, Observational Cohort Study.Neurology. Clinical practice · 2021Article
- Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination.Acta neuropathologica communications · 2020Article
- Pontine Myelinolysis Caused by Hypovolemic Hypernatremia.Case reports in nephrology · 2020Article
- Severe hypokalaemia in diabetic ketoacidosis: a contributor to central pontine myelinolysis?Endocrinology, diabetes & metabolism case reports · 2019Article
- Review
- Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Article
- Normonatremic osmotic demyelination in the setting of acquired immune deficiency syndrome and malnutrition: case report and literature review.Journal of neurovirology · 2016Article
- Cost-effectiveness of tolvaptan for the treatment of hyponatraemia secondary to syndrome of inappropriate antidiuretic hormone secretion in Sweden.BMC endocrine disorders · 2016Article
- Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon.Case reports in medicine · 2016Article
- Hyponatremia Following High-Volume D5W Hydrodissection During Thermal Ablation.Cardiovascular and interventional radiology · 2016Article
- Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation?Annals of intensive care · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Central pontine myelinolysis (CPM) is a demyelinating condition affecting not only the pontine base, but also involving other brain areas. It usually occurs on a background of chronic systemic illness, and is commonly observed in individuals with alcoholism, malnutrition and liver disease. Studies carried out 25-30 years ago established that the principal etiological factor was the rapid correction of hyponatremia resulting in osmotic stress. This article reviews progress achieved since that time on its pathogenesis, focusing on the role of organic osmolytes, the blood-brain, barrier, endothelial cells, myelinotoxic factors triggered by osmotic stress, and the role of various factors that predispose to the development of CPM. These advances show great promise in providing novel therapeutic options for the management of patients afflicted with CPM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.