Evidence map›Paper›PMID 20182758›Full record

SynthesisNeurogenetics2010

Meta-analysis of association between variation in the PDE4D gene and ischemic cerebral infarction risk in Asian populations.

Xiaowei Xu, Xia Li, Jiejie Li, Ru Ou, Wenli Sheng

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 9 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 9 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  15. Association between phosphodiesterase 4D (PDE4D) SNP 87 and ischemic stroke: a meta-analysis.International journal of clinical and experimental medicine · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaowei XuDepartment of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Xia Li
Jiejie Li
Ru Ou
Wenli Sheng
The First Affiliated Hospital, Sun Yat-sen University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphodiesterase 4D (PDE4D) was found to be associated with increased risk of ischemic stroke by Iceland researchers in 2003. Replication studies have produced conflicting results. A recent meta-analysis reported that no genetic variant of PDE4D demonstrated a reproducible association with ischemic stroke, especially when analyzed with respect to white subjects exclusively. In this study, we aimed to determine the association between PDE4D and ischemic infarction risk in Asian populations. After collecting all case-control studies in English or Chinese related to the association between PDE4D and ischemic infarction in Asian people, strict selection criteria and exclusion criteria were determined, and a fixed or random effects model was used on the basis of heterogeneity. To measure the strength of the genetic association, a pooled odds ratio (OR) and 95% confidence interval (CI) were calculated for each gene variant. Publication bias was evaluated. None of the Asian subjects were heterozygous for SNP 45 or SNP 41. Only seven studies involving SNP 83 and SNP 87 had sufficient data to allow inclusion into meta-analyses. Statistically significant associations with ischemic infarction in the Asian populations were determined for SNP 83 C allele (OR, 1.22; 95% CI, 1.03-1.43) and SNP 83 CC genotype (OR, 1.42; 95% CI, 1.14-1.77), but not for SNP 83 CC + CT genotypes or SNP 87. PDE4D was associated with ischemic infarction risk in Asian people, and SNP 83 was an important biomarker.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgedAged, 80 and overAsian PeopleBrain IschemiaCerebral InfarctionCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4HumansMiddle AgedYoung AdultCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4PDE4D protein, human

Identifiers

PMID20182758
OpenAlexW2008022739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.