Evidence map›Paper›PMID 20182712›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2010

A review on the clinical uses of SPECT/CT.

Giuliano Mariani, Laura Bruselli, Torsten Kuwert, Edmund E Kim, Albert Flotats, Ora Israel, Maurizio Dondi, Naoyuki Watanabe

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. The Increasing Importance of Breast Cancer in the United Arab Emirates.Asia-Pacific journal of clinical oncology · 2026
    Review
  6. Review
  7. Article
  8. Clinical efficacy ofFrontiers in oncology · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. AI in SPECT Imaging: Opportunities and Challenges.Seminars in nuclear medicine · 2025
    Review
  13. Review
  14. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Recent Progress in Synthesis ofNuclear medicine and molecular imaging · 2024
    Review
  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuliano MarianiRegional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma 67, 56126 Pisa, Italy. g.mariani@med.unipi.it
Laura Bruselli
Torsten Kuwert
Edmund E Kim
Albert Flotats
Ora Israel
Maurizio Dondi
Naoyuki Watanabe

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the era when positron emission tomography (PET) seems to constitute the most advanced application of nuclear medicine imaging, still the conventional procedure of single photon emission computed tomography (SPECT) is far from being obsolete, especially if combined with computed tomography (CT). In fact, this dual modality imaging technique (SPECT/CT) lends itself to a wide variety of useful diagnostic applications whose clinical impact is in most instances already well established, while the evidence is growing for newer applications. The increasing availability of new hybrid SPECT/CT devices with advanced technology offers the opportunity to shorten acquisition time and to provide accurate attenuation correction and fusion imaging. In this review we analyse and discuss the capabilities of SPECT/CT for improving sensitivity and specificity in the imaging of both oncological and non-oncological diseases. The main advantages of SPECT/CT are represented by better attenuation correction, increased specificity, and accurate depiction of the localization of disease and of possible involvement of adjacent tissues. Endocrine and neuroendocrine tumours are accurately localized and characterized by SPECT/CT, as also are solitary pulmonary nodules and lung cancers, brain tumours, lymphoma, prostate cancer, malignant and benign bone lesions, and infection. Furthermore, hybrid SPECT/CT imaging is especially suited to support the increasing applications of minimally invasive surgery, as well as to precisely define the diagnostic and prognostic profile of cardiovascular patients. Finally, the applications of SPECT/CT to other clinical disorders or malignant tumours is currently under extensive investigation, with encouraging results in terms of diagnostic accuracy.

Indexed as

Endocrine System DiseasesHumansNeoplasmsNeurosecretory SystemsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed

Identifiers

PMID20182712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.