ReviewCold Spring Harbor perspectives in biology2010
Cytoskeletal mechanisms for breaking cellular symmetry.
Review in Cold Spring Harbor perspectives in biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration.Nature cell biology · 2026Article
- Model supports asymmetric regulation across the intercellular junction for collective cell polarization.PLoS computational biology · 2024Article
- Benefits and challenges of reconstituting the actin cortex.Cytoskeleton (Hoboken, N.J.) · 2024Review
- Blebology: principles of bleb-based migration.Trends in cell biology · 2024Review
- Mechanics of tensegrity cell units incorporating asymmetry and insights intoJournal of the Royal Society, Interface · 2023Article
- Cytoplasmic dynein1 intermediate-chain2 regulates cellular trafficking and physiopathological development iniScience · 2023Article
- Orientation of Cell Polarity by Chemical Gradients.Annual review of biophysics · 2022Review
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Dynamic conversion of cell sorting patterns in aggregates of embryonic stem cells with differential adhesive affinity.BMC developmental biology · 2021Article
- A hybrid stochastic-deterministic mechanochemical model of cell polarization.Molecular biology of the cell · 2020Article
- CompuCell3D Simulations Reproduce Mesenchymal Cell Migration on Flat Substrates.Biophysical journal · 2020Article
- Article
- Cytoskeletal tension actively sustains the migratory T-cell synaptic contact.The EMBO journal · 2020Article
- Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling.PLoS computational biology · 2019Article
- Density fields for branching, stiff networks in rigid confining regions.The European physical journal. E, Soft matter · 2019Article
- Self-organized stress patterns drive state transitions in actin cortices.Science advances · 2018Article
- Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo.Nature communications · 2017Article
- Extracellular Matrix Revisited: Roles in Tissue Engineering.International neurourology journal · 2016Review
- Adult Stem Cell Responses to Nanostimuli.Journal of functional biomaterials · 2015Review
- Balance between cell-substrate adhesion and myosin contraction determines the frequency of motility initiation in fish keratocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Cytoskeletal systems are networks of polymers found in all eukaryotic and many prokaryotic cells. Their purpose is to transmit and integrate information across cellular dimensions and help turn a disorderly mob of macromolecules into a spatially organized, living cell. Information, in this context, includes physical and chemical properties relevant to cellular physiology, including: the number and activity of macromolecules, cell shape, and mechanical force. Most animal cells are 10-50 microns in diameter, whereas the macromolecules that comprise them are 10,000-fold smaller (2-20 nm). To establish long-range order over cellular length scales, individual molecules must, therefore, self-assemble into larger polymers, with lengths (0.1-20 m) comparable to the size of a cell. These polymers must then be cross-linked into organized networks that fill the cytoplasm. Such cell-spanning polymer networks enable different parts of the cytoplasm to communicate directly with each other, either by transmitting forces or by carrying cargo from one spot to another.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.