SynthesisJournal of human hypertension2010
Effect of isometric exercise on resting blood pressure: a meta analysis.
Synthesis in Journal of human hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04467879 (A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients), which is not on this map. Cited by 40 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients
Who cites it
40 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effects of different types of exercise on hypertension in middle-aged and older adults: a network meta-analysis.Frontiers in public health · 2023Pooled it
- The effectiveness and safety of isometric resistance training for adults with high blood pressure: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Pooled it
- A Systematic Review and Meta-Analysis on the Longitudinal Effects of Unilateral Knee Extension Exercise on Muscle Strength.Frontiers in sports and active living · 2020Pooled it
- Resting blood pressure reductions following handgrip exercise training and the impact of age and sex: a systematic review and narrative synthesis.Systematic reviews · 2018Pooled it
- Isometric exercise training for blood pressure management: a systematic review and meta-analysis to optimize benefit.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Pooled it
- Exercise training for blood pressure: a systematic review and meta-analysis.Journal of the American Heart Association · 2013Pooled it
- Handgrip and Acute Hemodynamic Responses During Cyclic Exercise: Randomized Clinical Trial.Journal of clinical hypertension (Greenwich, Conn.) · 2026Trial
- Trial
- Kinetics of Hypotension during 50 Sessions of Resistance and Aerobic Training in Hypertensive Patients: a Randomized Clinical Trial.Arquivos brasileiros de cardiologia · 2017Trial
- The efficacy of isometric resistance training utilizing handgrip exercise for blood pressure management: A randomized trial.Medicine · 2016Trial
- Time course of cardiovascular responses to acute sustained handgrip exercise in young physically active men.Physiological reports · 2025Article
- Toward a roadmap for addressing today's health dilemma-The 101-statement consensus report.Frontiers in nutrition · 2025Article
- The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency?Frontiers in physiology · 2025Review
- Randomised controlled effectiveness study (RCT) of isometric exercise (IE) in adults with stage 1 and 2 hypertension - ISOFITTER study.NIHR open research · 2025Article
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- An evidence-based guide to the efficacy and safety of isometric resistance training in hypertension and clinical implications.Clinical hypertension · 2023Review
- Getting the best GRIP on blood pressure control: Investigating a cost-effective isometric handgrip alternative.Chronic illness · 2022Article
- Implementation of non-pharmacological interventions for the treatment of hypertension in primary care: a narrative review of effectiveness, cost-effectiveness, barriers, and facilitators.BMC primary care · 2022Review
- Muscular Strength in Risk Factors for Cardiovascular Disease and Mortality: A Narrative Review.Anatolian journal of cardiology · 2022Review
- Is Exercise Blood Pressure Putting the Brake on Exercise Rehabilitation after Acute Type A Aortic Dissection Surgery?Journal of clinical medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dynamic physical exercise (walking, swimming, and so on) is an important component of lifestyle changes to reduce blood pressure; however, many individuals are unwilling or unable to adopt this lifestyle change. Isometric exercise has not traditionally been recommended as an alternative to dynamic exercise and has not been well studied. A meta-analysis of controlled trials of isometric exercise on resting blood pressure was therefore undertaken. Five trials were identified including a total of 122 subjects. Isometric exercise for <1 h per week reduced systolic blood pressure by 10.4 mm Hg and diastolic blood pressure by 6.7 mm Hg. These changes are similar to those achieved with a single pharmacological agent. These results suggest that isometric exercise may be of value as part of lifestyle advice in maintaining a desirable blood pressure.
Indexed as
Identifiers
20182455What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.